677773-59-0Relevant academic research and scientific papers
An iminophosphorane-based approach for the synthesis of spiropyrrolidine-imidazole derivatives
Fresneda, Pilar M.,Casta?eda, Marta,Sanz, Miguel Angel,Bautista, Delia,Molina, Pedro
, p. 1849 - 1856 (2007)
A method based on the reaction of an E-phosphazide, an intermediate in the Staüdinger reaction between triphenylphosphine and an azide, with heterocumulenes allows the one-pot, two-component synthesis of a number of pyrrole-imidazole derivatives. The proc
Trapping of a phosphazide intermediate in the Staudinger reaction of tertiary phosphines with azides and its application to the synthesis of analogs of the marine alkaloid midpacamide
Fresneda, Pilar M.,Casta?eda, Marta,Sanz, Miguel A.,Molina, Pedro
, p. 1655 - 1657 (2007/10/03)
A new method based on the reaction of an E-phosphazide, an intermediate in the Staudinger reaction between triphenylphosphine with an azide, with heterocumulenes allows the one-pot, two-component synthesis of a number of analogs of the pyrrole-imidazole marine alkaloid midpacamide. The procedure, which involves sequential treatment of the appropriate α-azido ester with triphenylphosphine and isothiocyanate leads to the thiohydantoin product after aqueous workup. The cyclization conditions can also be adapted to the synthesis of hydantoins by using isocyanates.
