6778-51-4Relevant academic research and scientific papers
Biotransformation of prim-O-glucosylcimifugin by human intestinal flora and its inhibition on NO production and DPPH free radical
Zhao, Bo,Yang, Xiu-Wei,Yang, Xin-Bao,Liu, Jian-Xun
, p. 886 - 896,11 (2012)
prim-O-Glucosylcimifugin (PGCN), a highest content chromone in the roots of Saposhnikovia divaricata, was incubated with human intestinal flora (HIF), and two biotransformation products were obtained from the incubated solution by chromatographic methods. The chemical structures of the two biotransformation products were elucidated as cimifugin (CN) and 5-O-methylvisamminol (MVL), respectively, on the basis of NMR and MS data. The biotransformation product CN was formed through a deglucosylation of PGCN by -glucosidase secreted from the HIF, and then the hydroxymethyl group of CN was reduced to lead to occurrence of MVL. All of these compounds were evaluated for their effect on the inhibition of nitric oxide production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and for 1,1-diphenyl-2-picrylhydrazyl free-radical scavenging activity in cell-free bioassay system.
METHOD OF PRODUCING 4'-O-GLUCOSYL-5-O-METHYLVISAMMINOL
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, (2016/10/08)
PROBLEM TO BE SOLVED: To provide a chemical synthesis method for 4'-O-glucosyl-5-O-methylvisamminol used in a quality control test of Chinese medicine extract comprising Saposhnikovia roots. SOLUTION: According to a method of this invention, an acyl group is detached from a compound of a formula (2) (where R represents an acyl group) and an obtained diastereomer is separated to produce a compound of a formula (1). COPYRIGHT: (C)2015,JPOandINPIT
