67786-53-2

Usage

Uses

Used in Pharmaceutical Industry:
6,9-DIOXO-11ALPHA,15S-DIHYDROXY-PROST-13E-EN-1-OIC ACID is used as a therapeutic agent for its vasodilatory properties. It helps in preventing the formation of platelet plugs, which can lead to blood clots and other cardiovascular issues. Its ability to dilate blood vessels makes it a valuable compound in the treatment of various cardiovascular diseases.
Used in Research Applications:
6-Keto-PGE1 is also used as a research tool to study the mechanisms of prostacyclin and its role in physiological processes. It aids scientists in understanding the complex interactions between eicosanoids and their receptors, which can contribute to the development of new drugs and therapies for various conditions.

InChI:InChI=1/C20H32O6/c1-2-3-4-7-14(21)10-11-16-17(19(24)13-18(16)23)12-15(22)8-5-6-9-20(25)26/h10-11,14,16-18,21,23H,2-9,12-13H2,1H3,(H,25,26)/b11-10+/t14-,16+,17+,18+/m0/s1

Upstream product

• 14273-90-6 methyl 6-bromohexanoate 
• 88462-11-7 Methyl 6-nitro-6-heptenoate 
• 92077-99-1 11,15-O-Bis(tert-butyldimethylsilyl)-6-nitro-PGE₁ methyl ester 
• 96243-99-1 7-{(1S,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-oxo-cyclopentyl}-6-oxo-heptanoic acid methyl ester 
• 84288-50-6 6-Keto-prostaglandin E₁ methyl ester bis-tert-butyldimethylsiloxy ether 
• 61305-35-9 (R)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-enone 
• 103081-30-7 11,15-bis-O-(t-butyldimethylsilyl)-6-hydroxyimino-PGE₁ methyl ester 
• 112329-43-8 7-Hydroxy-6-nitro-heptanoic acid methyl ester 
• 13154-40-0 6-nitrohexanoic acid methyl ester 
• 67786-49-6 6-oxo-PGE₁ methyl ester 

Relevant academic research and scientific papers

Nitro-Olefin Trapping Reactions of Enolates In Situ Generated by Conjugate Addition Reaction: Short Syntheses of PGE1, 6-Oxo-PGE1, 6-Oxo-PGF1α, and PGI2

The nitro-olefin trapping of the enolates in situ generated by conjugate addition of organocopper reagents to the chiral oxygenated cyclopentenone synthon, R-4, gives the three-component coupling products in a regiospecific manner.The intermediary nitronate anion 17 is further transformed into the nitro compound or 6-oxo-PGE1 (19) in a single pot.This coupling reaction is applicable to syntheses of naturally occurring prostaglandins such as PGE1, 6-oxo-PGF1α, and PGI2.