6779-66-4

Basic information

• Product Name: P,P-diphenylphosphinic hydrazide
• CAS NO: 6779-66-4
• Molecular Formula: C₁₂H₁₃N₂OP
• Molecular Weight: 232.2182
• Mol File: 6779-66-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 385.5°C at 760 mmHg
• Flash Point: 186.9°C
• Density: 1.23g/cm³
• Vapor Pressure: 3.8E-06mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: P,P-diphenylphosphinic hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: P,P-diphenylphosphinic hydrazide(6779-66-4)
• EPA Substance Registry System: P,P-diphenylphosphinic hydrazide(6779-66-4)

Safety Data

• Hazardous Substances Data: 6779-66-4(Hazardous Substances Data)

Upstream product

• 56426-26-7 1-Diphenylphosphoryl-5-phenyl-3-pyrazolcarbonsaeure-methylester 
• 1499-21-4 Diphenylphosphinic chloride 
• 66407-91-8 Ethyl α-diphenylphosphinylphenylacetate 

Downstream Products

• 70629-55-9 C₁₆H₂₁N₂OP 
• 151238-04-9 C₂₀H₂₀N₃OPS 
• 30426-16-5 1-diphenylphosphinoyl-4-phenyl-thiosemicarbazide 
• 30426-23-4 1-Diphenylphosphinyl-4-(p-chlorphenyl)-thiosemicarbazid 
• 30426-19-8 1-diphenylphosphinoyl-4-m-tolyl-thiosemicarbazide 
• 49789-51-7 N'-cyclohexylidene-P,P-diphenylphosphinic hydrazide 
• 49789-53-9 C₁₅H₁₇N₂OP 
• 49789-45-9 C₂₁H₂₂N₃OP 
• 51764-22-8 Diphenylphosphinsaeure-pikrylhydrazid 
• 30426-25-6 1-Diphenylphosphinyl-4-ethyl-thiosemicarbazid 
• 30426-18-7 1-diphenylphosphinoyl-4-isopropyl-thiosemicarbazide 
• 30426-24-5 1-Diphenylphosphinyl-4-methyl-thiosemicarbazid 

Relevant articles and documents

Light-Enabled Radical 1,4-Aryl Migration Via a Phospho-Smiles Rearrangement

Rearrangement reactions in organic chemistry are attractive strategies to build efficiently complex scaffolds, in just one step, from simple starting materials. Among them, aryl migrations are certainly one of the most useful and straightforward rearrangement for building attractive carbon-carbon bonds. Of note, anionic aryl migration reactions have been largely described compared to their radical counterparts. Recently, visible-light catalysis has proven its efficiency to generate such radical rearrangements due to the concomitant loss of a particle (often CO2 or SO2), which is the driving-force of the reaction. Here, we disclose a Smiles-type rearrangement, triggered by a phosphorus-containing unit (arylphosphoramidate), therefore called "phospho-Smiles"rearrangement, allowing a Csp2-Csp2 bond formation thanks to a 1,4-aryl migration reaction. In addition, combining this approach with a radical hydroamination/amination reaction produces an amination/phospho-Smiles cascade particularly attractive, for instance, to investigate the synthesis of the phthalazine core, a scarcely described scaffold of interest for medicinal chemistry projects.

Reactions of hydrazine with α-(diphenylphosphinyl)-ω-phenylalkanoic esters

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