6779-80-2Relevant academic research and scientific papers
Method for preparing isoproterenol sulfate dihydrate
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Paragraph 0021, (2017/09/01)
The invention relates to a method for preparing isoproterenol sulfate dihydrate. The method comprises the following steps: (1) preparation of 2-bromo-1-(3, 4-dihydroxy phenyl)-ethanone; (2) preparation of isoproterenol ketone hydrochloride; and (3) preparation of isoproterenol sulfate dihydrate. The method disclosed by the invention adopts a reaction system of bromoacetyl bromide and aluminium chloride instead of a reaction system of monochloro acetic acid and phosphorus oxychloride, so that the method has the advantages that the environmental protection cost is reduced; the reaction yield is increased; the industrial production is benefited; the reaction condition is mild; the catalyst quantity is little; and the process is simple. Compared with conventional synthetic processes, the method disclosed by the invention has obvious economic benefit and environmental benefit.
