67803-85-4

Upstream product

• 100-01-6 4-nitro-aniline 
• 123-54-6 acetylacetone 

Downstream Products

• 130103-07-0 {1-[4-(3,5-Dimethyl-pyrazol-1-yl)-benzenesulfonyl]-3,5-dimethyl-1H-pyrazol-4-yl}-(4-nitro-phenyl)-diazene 
• 130103-01-4 C₂₂H₂₃N₇O₅S 
• 1198352-71-4 C₂₃H₁₉N₅O₆ 
• 1239368-77-4 C₂₈H₂₁N₉O₂ 
• 34173-71-2 1-benzoyl-3,5-dimethyl-4-(4-nitro-phenylazo)-1H-pyrazole 
• 98077-68-0 [3,5-Dimethyl-4-(4-nitro-phenylazo)-pyrazol-1-yl]-pyridin-2-yl-methanone 
• 1309479-25-1 C₁₈H₁₅N₅O₄ 
• 1398415-48-9 1-[3-methyl-2-(4-nitrophenyldiazenyl)-2H-aziren-2-yl]ethanone 
• 1398415-17-2 C₁₁H₁₂N₄O₄ 
• 1169829-30-4 4-acetyl-2-(4-nitrophenyl)-5-methyl-1-vinyl-2,3-dihydro-1H-1,2,3-triazole 
• 1169829-17-7 4-acetyl-2-(4-nitrophenyl)-5-methyl-N-(2-hydroxyethyl)-2,3-dihydro-1H-1,2,3-triazole 
• 59972-38-2 3,5-dimethyl-4-(4-nitro-phenylazo)-isoxazole 

Relevant academic research and scientific papers

A novel approach to the synthesis of 1,2,3-triazoles and their SAR studies

A series of biologically active 4-acetyl-2-aryl-5-methyl-1-vinyl-2,3- dihydro- 1H-1,2,3-triazole derivatives has been synthesized. The compounds were synthesized in excellent yields (80-85%) and the structures were established on the basis of corresponding IR, 1H NMR, and elemental analysis data. The purity has been ascertained on the basis of chromatographic resolution using acetic acid-toluene (4:6 v/v) as binary eluent. All the compounds (4a-l) have been tested for their antifungal activity against a representative panel of fungal microbes. These synthesized compounds exhibited significant activities against A. niger, C. albicans, C. azyma, and A. flavus. For all the tests conducted, voriconazole was used as the control drug. The hydrophobic parameter (log P) also has been quantized for correlation of structure with biological activity, and a critical evaluation of structure-activity relationship (SAR) has been performed. Birkhaeuser Boston 2009.

Synthesis and QSAR modeling 1-[3-methyl-2-(aryldiazenyl)-2H-aziren-2-yl] ethanones as potential antibacterial agents

The present communication deals with the synthesis of a series of 1-[3-methyl-2-(aryldiazenyl)-2H-aziren-2-yl]ethanones. The compounds were synthesized in excellent yields (70-80 %), and the structures were established on the basis of consistent IR, 1H NMR, and elemental analysis data. The purity has been ascertained by chromatographic resolution using hexane-ethyl acetate (6:4 v/v) as binary eluent. All the compounds have been tested for their antimicrobial activity against a representative panel of bacteria i.e., Bacillus subtilis, Escherichia coli, Pseudomonas diminuta, and Staphylococcus aureus using Chloramphenicol as reference drug. All the synthesized compounds were found to exhibit profound antimicrobial activity.

Pyridazine derivatives and related compounds. 23*. synthesis of 3-substituted pyrazolo[3,4-c] pyridazines and their application as disperse dyes

Acetylacetone and malononitrile were coupled with diazotized arylamines to give arylazoacetylacetones and arylazomalononitriles. When refluxed with 3-hydrazino-4,5-diphenyl-1H-pyrazolo-[3,4-c]pyridazine in the presence of ethanol/HCl, they yielded the corresponding 3-[4-(arylazo)-3,5-dimethylpyrazol- 1-yl]- and 3-[3,5-diamino-4-(arylazo)pyrazol-1-yl]-4,5-diphenyl-1H-pyrazolo[3,4- c]pyridazine dyes. The dyes were applied to polyester and polyamide fabrics, and their spectral and fastness properties were measured.