67808-93-9

Upstream product

• 67808-91-7 (Z)-1-nitro-1-(phenylthio)propene 
• 126-81-8 dimedone 
• 103-04-8 (phenylthio)acetic acid 
• 67808-90-6 1-nitro-1-(phenylthio)-2-propanol 
• 60595-16-6 (phenylthio)nitromethane 
• 22103-05-5 1-(phenylthio)-1-propene 
• 69477-90-3 3-Hydroxy-5,5-dimethyl-2-(1-methyl-2-nitro-2-phenylsulfanyl-ethyl)-cyclohex-2-enone 

Downstream Products

• 69477-91-4 (2R,3S)-2-Benzenesulfinyl-3,6,6-trimethyl-3,5,6,7-tetrahydro-2H-benzofuran-4-one 

Relevant academic research and scientific papers

Efficient synthesis of dihydrofurans with sulfide groups by ceric(IV) ammonium nitrate-mediated oxidative cycloaddition of 1,3-dicarbonyl compounds to vinyl sulfides. Application to the synthesis of benzo[b]naphtho[2,3-d]furan-6,11-dione and first total synthesis of millettocalyxins C and pongamol methyl ether

Ceric(IV) ammonium nitrate-mediated oxidative cycloaddition of 1,3-dicarbonyls to vinyl sulfides afforded substituted dihydrofurans with sulfide groups in moderate yields. This new synthetic method has been applied to the synthesis of benzo[b]naphtho[2,3-d]furan-6,11-dione and furanoflavone natural products such as millettocalyxins C and pongol methyl ether.

1-Nitro-1-(phenylthio)propene as a New Nitro Olefin Reagent for 3-Methylfuran Annulation and Its Application to the Synthesis of Some Furanoterpenoids

1-Nitro-1-(phenylthio)propene (9) was synthesized from (phenylthio)acetic acid (6) in five steps.This nitro olefin reacted with dimedone (1) with KF catalysis to yield dihydrofurans 10a and 10b, both of which were converted to 3-methylfuran 13 on NaIO4 ox