67812-42-4

Basic information

• Product Name: NORVERAPAMIL HYDROCHLORIDE
• Synonyms: NORVERAPAMIL HCL;NORVERAPAMIL HYDROCHLORIDE;(+/-)-VERAPAMIL, NOR-METHYL-, HYDROCHLORIDE;(+-)-VERAPAMIL HYDROCHLORIDE, NOR-METHYL (NORVERAPAMIL HYDROCH;a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)- benzeneacetonitril;n-nor-(±)-verapamil hydrochloride;α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)- benzeneacetonitrile;a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile
• CAS NO: 67812-42-4
• Molecular Formula: C26H37ClN2O4
• Molecular Weight: 477.04
• Product Categories: Various Metabolites and Impurities;Metabolites
• Mol File: 67812-42-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: softens at 50°C, 155-160°C dec.
• Boiling Point: 586.1°Cat760mmHg
• Flash Point: 9℃
• Appearance: white/solid
• Density: 1.063g/cm³
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: H2O: >10 mg/mL
• Stability: Hygroscopic
• CAS DataBase Reference: NORVERAPAMIL HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: NORVERAPAMIL HYDROCHLORIDE(67812-42-4)
• EPA Substance Registry System: NORVERAPAMIL HYDROCHLORIDE(67812-42-4)

Safety Data

• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 67812-42-4(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Crystalline Solid

Uses

Nor Verapamil Hydrochloride (Verapamil EP Impurity J HCl) is a metabolite of Verapamil.

General Description

Norverapamil is a primary urinary metabolite of verapamil, a calcium channel blocker used in the treatment of hypertension, angina pectoris, and cardiac arrhythmia. Verapamil is also an effective preventive medication for migraines. This Certified Reference Material is applicable for use as starting material in calibrators or controls for verapamil testing methods by LC-MS/MS or GC-MS.

Biochem/physiol Actions

Norverapamil is an N-demethylated metabolite of verapamil. It has significantly less calcium channel blocking ability and exhibit therapeutic activity.

InChI:InChI=1/C26H36N2O4.ClH/c1-19(2)26(18-27,21-9-11-23(30-4)25(17-21)32-6)13-7-14-28-15-12-20-8-10-22(29-3)24(16-20)31-5;/h8-11,16-17,19,28H,7,12-15H2,1-6H3;1H