678142-02-4Relevant academic research and scientific papers
A two-step, one pot preparation of amines via acyl succinimides. Synthesis of the calcimimetic agents cinacalcet, NPS R-467, and NPS R-568
Gooodman, Cassie A.,Janci, Elise Marie,Onwodi, Olivia,Simpson, Chad C.,Hamaker, Christopher G.,Hitchcock, Shawn R.
, p. 4468 - 4471 (2015)
Abstract A method has been developed for the preparation of amines through a process of coupling acyl succinimides derived from commercially available carboxylic acids with amines to afford the corresponding amides. These amides are then reduced in situ with either diisobutylaluminum hydride or lithium aluminum hydride. The reaction tandem of the coupling reaction followed by the reduction affords the amine in fair to good yields after purification by flash chromatography. This one-pot, two reaction tandem process has been successfully applied to the synthesis of the calcimimetic agents cinacalcet, NPS R-467, and NPS R-568.
Aerobic amide bond formation with N-hydroxysuccinimide
Yao, Haoyi,Yamamoto, Kana
supporting information; experimental part, p. 1542 - 1545 (2012/09/08)
Breathe easy: Molecular oxygen is one of the most abundant, atom-efficient, and economical oxidants. An aerobic oxidative amide formation from aldehydes and amines is reported. The method uses a catalytic amount of Co(OAc) 2 and N-hydroxysuccinimide as reaction promoters. It is applicable to chiral substrates without loss of their optical purity. Copyright
