678143-40-3Relevant articles and documents
Effective irreversible alkylating reagents based on the structure of clavulones
Tanaka, Hiroshi,Kitade, Makoto,Iwashima, Makoto,Iguchi, Kazuo,Takahashi, Takashi
, p. 837 - 840 (2004)
We describe the design and synthesis of alkylating reagents based on the structure of clavulones. They are composed of cross-conjugated dienone system and irreversibly reacted with two nucleophiles under mildly basic conditions via β-elimination. Hydroxyl derivative 7b showed the highest reactivity toward thiols and showed the strongest cytotoxicity in Hela S3 cells among the three derivatives having a different protecting group at the tert-hydroxyl group.