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The chemical compound "(3aR,4R,6R,10Z,11aR)-3a,5,6,11a-Tetrahydro-4-hydroxy-6,10-dimethyl-3-methylene-6,9-epoxycyclodeca[b]furan-2,7(3H,4H)-dione" is a complex organic molecule with a unique structure. It features a cyclodeca[b]furan ring system, which is a type of cyclic compound with a furan ring fused to a cyclodecane ring. The compound has a tetrahydro (partially hydrogenated) structure, with a 3-methylene group indicating the presence of a carbon-carbon double bond that has been reduced to a single bond with the addition of hydrogen. It also contains a 4-hydroxy group, which is a hydroxyl (-OH) group attached to a carbon atom, and two methyl groups at positions 6 and 10, which are alkyl groups consisting of a single carbon atom bonded to three hydrogen atoms. The molecule has a 6,9-epoxy bridge, which is an oxygen-containing three-membered ring structure, and a 2,7-dione group, indicating the presence of two carbonyl groups (C=O) at these positions. The stereochemistry of the compound is specified by the R configuration at several chiral centers, which refers to the spatial arrangement of atoms around these centers. (3aR,4R,6R,10Z,11aR)-3a,5,6,11a-Tetrahydro-4-hydroxy-6,10-dimethyl-3-methylene-6,9-epoxycyclodeca[b]furan-2,7(3H,4H)-dione is likely to be found in natural products or synthesized for specific applications due to its intricate structure and functional groups.

67815-63-8

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67815-63-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 67815-63-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,8,1 and 5 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 67815-63:
(7*6)+(6*7)+(5*8)+(4*1)+(3*5)+(2*6)+(1*3)=158
158 % 10 = 8
So 67815-63-8 is a valid CAS Registry Number.

67815-63-8Upstream product

67815-63-8Relevant academic research and scientific papers

Identification of a Covalent Importin-5 Inhibitor, Goyazensolide, from a Collective Synthesis of Furanoheliangolides

Barluenga, Sofia,Liu, Weilong,Loewith, Robbie,Patouret, Rémi,Plank, Michael,Winssinger, Nicolas

, p. 954 - 962 (2021/06/28)

Sesquiterpenes are a rich source of covalent inhibitors with a long history in traditional medicine and include several important therapeutics and tool compounds. Herein, we report the total synthesis of 16 sesquiterpene lactones via a build/couple/pair strategy, including goyasensolide. Using an alkyne-tagged cellular probe and proteomics analysis, we discovered that goyazensolide selectively targets the oncoprotein importin-5 (IPO5) for covalent engagement. We further demonstrate that goyazensolide inhibits the translocation of RASAL-2, a cargo of IPO5, into the nucleus and perturbs the binding between IPO5 and two specific viral nuclear localization sequences.

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