678150-56-6

Basic information

• Product Name: m-PEG7-4-nitrophenyl carbonate
• Synonyms: m-PEG7-4-nitrophenyl carbonate
• CAS NO: 678150-56-6
• Molecular Formula: C20H31NO11
• Molecular Weight: 461.46
• Mol File: 678150-56-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: m-PEG7-4-nitrophenyl carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: m-PEG7-4-nitrophenyl carbonate(678150-56-6)
• EPA Substance Registry System: m-PEG7-4-nitrophenyl carbonate(678150-56-6)

Safety Data

• Hazardous Substances Data: 678150-56-6(Hazardous Substances Data)

Usage

Description

m-PEG7-4-nitrophenyl carbonate is a PEG (polyethylene glycol) linker with a nitrophenyl carbonate group. This molecule is characterized by its ability to react with the amine groups of lysine residues, forming a stable urethan linkage. The nitrophenyl carbonate serves as an effective leaving group, which makes it a versatile component in various applications.

Uses

Used in Pharmaceutical Industry:
m-PEG7-4-nitrophenyl carbonate is used as a conjugation agent for enhancing the solubility, stability, and bioavailability of therapeutic proteins and peptides. The stable urethan linkage formed with lysine residues improves the pharmacokinetic properties of the conjugated molecules, leading to better therapeutic outcomes.
Used in Drug Delivery Systems:
In the field of drug delivery, m-PEG7-4-nitrophenyl carbonate is utilized as a key component in the design of targeted drug carriers. The PEG linker provides stealth properties, reducing the immunogenicity and non-specific uptake of the drug carrier, while the nitrophenyl carbonate group allows for specific and efficient conjugation to therapeutic molecules, ensuring precise drug delivery to the desired site of action.
Used in Bioconjugation and Diagnostics:
m-PEG7-4-nitrophenyl carbonate is employed as a bioconjugation agent in the development of diagnostic tools and imaging agents. The stable urethan linkage enables the covalent attachment of various diagnostic molecules, such as fluorescent dyes or radioisotopes, to biomolecules like antibodies or peptides, facilitating the detection and monitoring of specific biological processes or disease markers.
Used in Material Science:
In the material science field, m-PEG7-4-nitrophenyl carbonate is used as a building block for the synthesis of novel biocompatible materials. The PEG linker and nitrophenyl carbonate group can be incorporated into polymeric structures, providing enhanced properties such as improved hydrophilicity, biocompatibility, and controlled degradation, which are essential for various biomedical applications, including tissue engineering and implantable devices.