678173-22-3Relevant academic research and scientific papers
A novel Pd-catalyzed cyclization reaction of ureas for the synthesis of dihydroquinazolinone p38 kinase inhibitors
Schlapbach, Achim,Heng, Richard,Di Padova, Franco
, p. 357 - 360 (2007/10/03)
A series of potent p38 inhibitors based on the dihydroquinazoline scaffold was synthesized using a novel Pd-catalyzed cyclization reaction of aryl-benzyl ureas. Optimization of this compound class led to compound 20, which inhibits p38α in vitro with IC50=14 nM and is active in the mouse TNFα-release model.
