67818-83-1Relevant academic research and scientific papers
Synthesis of new amidophosphite ligand and its application in Ir-catalyzed asymmetric hydrogenation of heterocyclic compounds
Lyubimov,Ozolin,Pavlov,Fedorova,Velezheva,Davankov
, p. 1405 - 1408 (2014/05/06)
A new chiral amidophosphite ligand was synthesized and tested in the iridium-catalyzed hydrogenation of heterocyclic compounds. The enantioselectivity of hydrogenation of 2-methyl- quinoline considerably increases when piperidine hydrochloride is used as an additive. The hydrogenation reaction of 8-methyl-2,4,5,6-tetrahydro-1H-pyrazino[3,2,1-jk] carbazole by metal complex was conducted for the first time to prepare enantiomerically enriched anti- depressant Pyrazidol.
