67819-48-1Relevant academic research and scientific papers
Synthesis of peptides containing a sulfinamide or a sulfonamide transition-state isostere
Moree, Wilna J.,Van Gent, Liesbeth C.,Van Der Marel, Gijs A.,Liskamp, Rob M. J.
, p. 1133 - 1150 (1993)
A versatile synthesis of peptides incorporating the sulfinamide or sulfonamide transition-state analogue is described. Apart from the easily accessible Gly-Xxx isosteres used as haptens to elicit catalytic antibodies, other amino acids than Gly can be prepared by α-alkylation of the sulfonamide containing peptides. This is illustrated with the synthesis of a potential HIV-protease inhibitor 27.
