67838-55-5

Upstream product

• 942066-34-4 3-(benzyloxymethyl)-4,5-dihydro-isothiazole 1,1-dioxide 
• 2930-05-4 Benzyloxymethyl-oxiran 
• 67838-52-2 2-acetoxy-1-benzyloxybut-3-ene 
• 60656-87-3 benzyloxyacetoaldehyde 
• 67838-54-4 4-(Benzyloxy)-3-hydroxybutane-1-sulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 942066-43-5 tert-butyl N-[(3-hydroxy-4-(benzyloxy)butyl)sulfonyl]carbamate 

Relevant academic research and scientific papers

Synthesis of chiral γ-sultams through intramolecular reductive amination with sulfonylcarbamate as N-source

An efficient and enantioselective palladium-catalyzed intramolecular asymmetric reductive amination with sulfonylcarbamates as N-sources was reported, providing a facile and general access to the chiral γ-sultam derivatives with up to 97% of enantioselect

Highly enantioselective synthesis of sultams via Pd-catalyzed hydrogenation

(Chemical Equation Presented) Using pd(cf3co2) 2/(S,S)-f-Binaphane as the catalyst, an efficient enantioselective synthesis of sultams was developed via asymmetric hydrogenation of the corresponding cyclic imines with high

Highly enantioselective Pd-catalyzed asymmetric hydrogenation of activated imines

(Chemical Equation Presented) Pd/bisphosphines complexes are highly effective catalysts for asymmetric hydrogenation of activated imines in trifluoroethanol. The asymmetric hydrogenation of N-diphenylphosphinyl ketimines 3 with Pd(CF3CO2)/(S)-SegPhos indicated 87-99% ee, and N-tosylimines 5 could gave 88-97% ee with Pd-(CF3CO 2)/(S)-SynPhos as a catalyst. Cyclic N-sulfonylimines 7 and 11 were hydrogenated to afford the useful chiral sultam derivatives in 79-93% ee, which are important organic synthetic intermediates and structural units of agricultural and pharmaceutical agents.

8-Aza-9-dioxothiaprostanoic acids

Novel 8-aza-9-dioxothiaprostanoic acid compounds, their salts, and derivatives, are prepared from ethyl 7-(3-hydroxymethyl-2-isothiazolidinyl)-5-heptynoate S,S-dioxide by first hydrogenating the triple bond over a Lindlar catalyst, followed by mild oxidation, to produce the corresponding 3-formyl compound, which is condensed with the ylide prepared from dimethyl-(2-oxoheptyl)phosphonate to produce the α,β-unsaturated ketone, followed by reduction to the corresponding carbinol, and ester hydrolysis. The compounds are useful especially for the treatment of patients with poorly functioning kidneys, as hypotensives, or as platelet aggregation inhibitors.