67838-90-8Relevant academic research and scientific papers
Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus
Luo, Yu,Yao, Jia-Ping,Yang, Li,Feng, Chun-Lan,Tang, Wei,Wang, Gui-Feng,Zuo, Jian-Pin,Lu, Wei
experimental part, p. 5048 - 5055 (2010/09/05)
A series of novel benzimidazole derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compound 12a, with IC50 81.2, was the most promising compound and selected as the benchmark compound for further optimization.
A dichotomy in the Friedel-Crafts reaction of lactones provides a convenient new route to 2-acylated pyrroles and tetrahydroindolones
Harrowven,Dainty
, p. 6739 - 6742 (2007/10/02)
In striking contrast to arenes, N-methylpyrrole undergoes Friedel-Crafts acylation with lactones. The reaction is most efficient with γ- and δ-lactones; ε-lactones proceed with poor overall conversion while β-lactones display poor selectivity. γ-Alkyl-γ-lactones readily yield 4,5,6,7-tetrahydroindol-7-ones through a sequence analogous to the Truce-Olson annulation.
