67844-53-5

Usage

Uses

Used in Organic Synthesis:
N-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylformamide is used as a reagent in organic synthesis for its unique chemical properties. The presence of phenyl, formamide, and hydroxyl groups in the same molecule allows it to participate in various organic reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Catalyst Applications:
In the field of catalysis, N-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylformamide is used as a catalyst to facilitate and enhance the rate of chemical reactions. Its ability to interact with other molecules and promote reaction pathways makes it a useful catalyst in various industrial processes.
Used in Solvent Applications:
N-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylformamide is also used as a solvent in organic reactions. Its solvation power, attributed to the hydroxyl and formamide groups, enables it to dissolve a wide range of organic compounds, making it a versatile solvent in the chemical industry.
Used in Pharmaceutical Industry:
N-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylformamide is used as an intermediate in the synthesis of pharmaceutical compounds. Its unique structure and reactivity make it a key component in the development of new drugs and therapeutic agents.
Used in Chemical Research:
In the field of chemical research, N-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylformamide is used as a research tool to study the properties and behavior of complex organic molecules. Its unique structure provides insights into the mechanisms of various chemical reactions and interactions.

Upstream product

• 299-42-3 ephedrine 
• 111333-97-2 formic acid pentafluorophenyl ester 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 109-94-4 formic acid ethyl ester 
• 321-98-2 (1S,2R)-(+)-ephedrine 
• 90-82-4 pseudoephedrine 
• 72179-93-2 aminomethylene-malonic acid dimethyl ester 
• 1668-82-2 (2S,4S)-3,4-dimethyl-5-phenyl-1,3-oxazolidine 

Relevant academic research and scientific papers

A novel type of N-formylation and related reactions of amines via cyanides and esters as formylating agents

A novel N-formylation and related reactions proceed from cyanides promoted by esters. The Royal Society of Chemistry.

A PROCESS FOR THE PREPARATION OF R-(-)-N, α-DIMETHYLPHENETHYLAMINE (LEVMETAMFETAMINE) OR S-(+)-N, α-DIMETHYLPHENETHYLAMINE (METHAMPHETAMINE) FROM d-EPHEDRINE OR L-EPHEDRINE RESPECTIVELY

A process for synthesis of R-(-)-N, α -Dimethylphenethylamine (Levmetamfetamine, formula I), or S-(+)-N, α - Dimethyl phenethylamine (Methamphetamine, formula II ), from d-ephedrine of formula III or l-ephedrine formula IV, the process comprising the steps of (a) acylating the d- or l-ephedrine base of formula III or formula IV with an acylating agent to make a reaction mixture containing a N- acylated ephedrines of formula V or formula VI ; (b) deoxygenation of N-acylated ephedrines to make the compound of the formula VII or Formula VIII by using Raney Nickel catalyst ; and (c) acid hydrolysis of the above deoxygenated products to get the levmetamfetamine or methamphetamine.

Unusually facile palladium catalysed oxidation of imidazolidines and oxazolidines

An unusually facile palladium catalysed oxidation of imidazolidines is described, affording in good yield, the monoamide of the corresponding diamine or the corresponding imidazolines. Oxazolidines derived from ephedrine react similarly.

Reactions of (-)-Ephedrine, (+)-Norpseudoephedrine and Derivatives with N,N-Dimethylacetamid-dimethylacetal and N,N-Dimethylformamid-dimethylacetal

The reactivity of (-)-ephedrine (2) and (+)-norpseudoephedrine (3) towards the amid-acetals 1 a/b has been studied.Both 2 and 3 were acetylated resp. formylated at first at the amino group.Nevertheless, derivatives of 2 and 3 possessing a trisubstituted amino group react with 1 a in a sigmatropic rearrangement to ortho substituted dimethylcarbamoylmethyl derivatives.By subsequent reduction with lithiumaluminiumhydride the aromatic compounds 8, 13, and 18 with two aminoethyl groups are easily available.In contrast to these results 1 b did not furnish any rearrangement products. Keywords. (-)-Ephedrine; (+)-Norpseudoephedrine; N,N-Dimethylacetamid-dimethylacetal; N,N-Dimethylformamid-dimethylacetal; Sympathomimetic effects; Sigmatropic rearrangements.

Rapid and Selective Formylation With Pentafluorophenyl Formate

Pentafluorophenyl formate reacts smoothly with N-nucleophiles under mild conditions to give the N-formyl derivatives, whereas O- and S-nucleophiles remain unaffected even in the presence of a tertiary base.