67844-53-5

Basic information

• Product Name: N-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylformamide
• CAS NO: 67844-53-5
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.2423
• Mol File: 67844-53-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 386.2°C at 760 mmHg
• Flash Point: 187.4°C
• Density: 1.104g/cm³
• Vapor Pressure: 1.18E-06mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: N-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylformamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylformamide(67844-53-5)
• EPA Substance Registry System: N-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylformamide(67844-53-5)

Safety Data

• Hazardous Substances Data: 67844-53-5(Hazardous Substances Data)

Usage

General Description

N-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylformamide is a complex organic compound, which belongs to the family of formamides. Like its similar compounds, it usually appears in the form of colourless to slightly yellow liquid, depending on its purity. It is predominantly used as a reagent, catalyst, or solvent in organic reactions due to its unique chemical properties. The presence of phenyl, formamide, and hydroxyl groups in the same molecule could be responsible for its reactivity and solvation power. It is synthesized through a sequence of organic reactions involving hydroxyphenylpropane and N-methylformamide. The safety and potential hazards associated with this chemical, however, can't be neglected and it requires proper handling and storage.

Upstream product

• 90-82-4 pseudoephedrine 
• 321-98-2 (1S,2R)-(+)-ephedrine 
• 109-94-4 formic acid ethyl ester 
• 1668-82-2 (2S,4S)-3,4-dimethyl-5-phenyl-1,3-oxazolidine 
• 299-42-3 ephedrine 
• 72179-93-2 aminomethylene-malonic acid dimethyl ester 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 111333-97-2 formic acid pentafluorophenyl ester 

Relevant articles and documents

A novel type of N-formylation and related reactions of amines via cyanides and esters as formylating agents

A novel N-formylation and related reactions proceed from cyanides promoted by esters. The Royal Society of Chemistry.

Unusually facile palladium catalysed oxidation of imidazolidines and oxazolidines

An unusually facile palladium catalysed oxidation of imidazolidines is described, affording in good yield, the monoamide of the corresponding diamine or the corresponding imidazolines. Oxazolidines derived from ephedrine react similarly.

Rapid and Selective Formylation With Pentafluorophenyl Formate

Pentafluorophenyl formate reacts smoothly with N-nucleophiles under mild conditions to give the N-formyl derivatives, whereas O- and S-nucleophiles remain unaffected even in the presence of a tertiary base.