67845-47-0Relevant academic research and scientific papers
Odor-structure relationships using fluorine as a probe
Michel, Dominique,Schlosser, Manfred
, p. 4253 - 4260 (2007/10/03)
Eight ethers, nine esters and one ketone were submitted to a systematic structural variation by replacing a hydrogen atom in the vicinity of the oxofunction by fluorine and methyl. As long as steric factors dominate, a fluorine substituent alters the olfactory properties of the parent compound much less than a methyl substituent does. However, if it occupies a position adjacent to a carbonyl group, the halogen may more profoundly affect the odor perception, presumably as a consequence of conformational changes. (C) 2000 Elsevier Science Ltd.
Process for the preparation of medium sized carbocyclic alkyl ethers
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, (2008/06/13)
An economically advantageous method is disclosed for the preparation without added solvent of a carbocyclic ether having from 10 to 16 carbon atoms in the ring of the formula STR1 wherein R is a straight or branched (C3 -C6) chain alkyl group or a benzyl group and n is from 5-11 carbon atoms, which method comprises: (1) reacting under an inert atmosphere a mixture consisting essentially of a carbocyclic alcohol of the formula STR2 wherein n is from 5-11 carbon atoms, about 1.5-10 molar equivalents of a straight or branch (C3 -C6) chain alkyl halide or benzyl halide and a metal hydride.
