67856-45-5

Basic information

• Product Name: 2H-1-Benzopyran, 3,4-dihydro-6-iodo-
• Synonyms: 2H-1-Benzopyran, 3,4-dihydro-6-iodo-;6-IodochroMan;6-Iodochromane;6-iodo-3,4-dihydro-2H-chromene
• CAS NO: 67856-45-5
• Molecular Formula: C₉H₉IO
• Molecular Weight: 260.07163
• Mol File: 67856-45-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 296.9±29.0 °C(Predicted)
• Appearance: /
• Density: 1.741±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2H-1-Benzopyran, 3,4-dihydro-6-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran, 3,4-dihydro-6-iodo-(67856-45-5)
• EPA Substance Registry System: 2H-1-Benzopyran, 3,4-dihydro-6-iodo-(67856-45-5)

Safety Data

• Hazardous Substances Data: 67856-45-5(Hazardous Substances Data)

Usage

General Description

2H-1-Benzopyran, 3,4-dihydro-6-iodo- is a chemical compound with the molecular formula C15H17IO. It belongs to the class of compounds known as benzopyrans, which are heterocyclic compounds containing a benzene ring fused to a pyran ring. The presence of an iodine atom in the 6th position of the pyran ring gives this compound its unique chemical and physical properties. 2H-1-Benzopyran, 3,4-dihydro-6-iodo- may be used in organic synthesis and pharmaceutical research due to its potential reactivity and biological activity. However, it is important to handle this compound with caution due to the potential hazards associated with iodine-containing chemicals. Overall, 2H-1-Benzopyran, 3,4-dihydro-6-iodo- is a valuable chemical compound with interesting potential applications in various fields.

Upstream product

• 493-08-3 chromane 
• 122-97-4 3-Phenyl-1-propanol 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 

Downstream Products

• 1002727-88-9 2-(chroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1300610-81-4 methyl N-[[2-chloro-5-[3-(3,4-dihydro-2H-1-benzopyran-6-yl)-1H-pyrazol-1-yl]phenyl]methyl]carbamate 
• 1300610-49-4 N-[[2-chloro-5-[1-(3,4-dihydro-2H-1-benzopyran-6-yl)-1H-pyrazol-3-yl]-phenyl]methyl]acetamide 
• 1300610-51-8 N-[[2-chloro-5-[1-(3,4-dihydro-2H-1-benzopyran-6-yl)-1H-pyrazol-3-yl]phenyl]methyl]formamide 
• 1300610-53-0 N-[[2-chloro-5-[1-(3,4-dihydro-2H-1-benzopyran-6-yl)-1H-pyrazol-3-yl]phenyl]methyl]-N-methylurea 
• 1418718-38-3 C₃₁H₃₃FN₂O₄ 
• 1418713-79-7 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(4-fluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid 
• 1418718-41-8 methyl 4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 
• 1418718-44-1 (4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol 
• 1418718-47-4 4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde 
• 1418718-53-2 C₂₉H₂₉F₂N₃O₂Si 
• 1418718-50-9 methyl 2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate 
• 1418718-56-5 methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate 
• 1418713-83-3 (R)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid 

Relevant articles and documents

Umpolung Strategy for Arene C?H Etherification Leading to Functionalized Chromanes Enabled by I(III) N-Ligated Hypervalent Iodine Reagents

The direct formation of aryl C?O bonds via the intramolecular dehydrogenative coupling of a C?H bond and a pendant alcohol represents a powerful synthetic transformation. Herein, we report a method for intramolecular arene C?H etherification via an umpoled alcohol cyclization mediated by an I(III) N-HVI reagent. This approach provides access to functionalized chromane scaffolds from primary, secondary and tertiary alcohols via a cascade cyclization-iodonium salt formation, the latter providing a versatile functional handle for downstream derivatization. Computational studies support initial formation of an umpoled O-intermediate via I(III) ligand exchange, followed by competitive direct and spirocyclization/1,2-shift pathways. (Figure presented.).

An efficient preparation of chroman derivatives from 3-aryl-1-propanols and related compounds with 1,3-diiodo-5,5-dimethylhydantoin under irradiation conditions

Treatment of various 3-aryl-1-propanols with 1,3-diiodo-5,5- dimethylhydantoin (DIH) in ethyl acetate or 1,2-dichloroethane under irradiation with a tungsten lamp gave the corresponding chroman derivatives in good to moderate yields. The present reaction proceeds via the initial formation of an alkoxyl radical and the radical cyclization onto the aromatic ring, followed by the oxidation of the formed radical intermediate with DIH to provide the chroman derivative. The same treatment of o-biphenyldimethylcarbinol, o-phenylbenzoic acid, and o-alkylbenzoic acids with DIH provided the corresponding chroman derivatives and lactone derivatives in good yields, respectively. Georg Thieme Verlag Stuttgart - New York.

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

Compounds of formula (I): wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.