67868-84-2

Basic information

• Product Name: 2-hydroxy-5-(methylthio)benzaldehyde
• Synonyms: 2-hydroxy-5-(methylthio)benzaldehyde;Benzaldehyde, 2-hydroxy-5-(methylthio)-;2-HYDROXY-5-(METHYLSULFANYL)BENZALDEHYDE
• CAS NO: 67868-84-2
• Molecular Formula: C₈H₈O₂S
• Molecular Weight: 168.21292
• EINECS: -0
• Mol File: 67868-84-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 114-118 °C(Press: 4 Torr)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 8.00±0.18(Predicted)
• CAS DataBase Reference: 2-hydroxy-5-(methylthio)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-5-(methylthio)benzaldehyde(67868-84-2)
• EPA Substance Registry System: 2-hydroxy-5-(methylthio)benzaldehyde(67868-84-2)

Safety Data

• Hazardous Substances Data: 67868-84-2(Hazardous Substances Data)

Usage

General Description

2-hydroxy-5-(methylthio)benzaldehyde is a chemical compound that contains a hydroxyl group, a benzene ring, and a thioether group. It is used in the preparation of pharmaceuticals and other organic compounds. 2-hydroxy-5-(methylthio)benzaldehyde has potential applications in the fragrance and flavor industry due to its aromatic properties. It is also used in the synthesis of dyes and pigments. Additionally, 2-hydroxy-5-(methylthio)benzaldehyde has been studied for its potential antioxidant and anti-inflammatory properties, making it a subject of interest in the field of medicinal chemistry.

Upstream product

• 1073-72-9 4-hydroxythioanisole 
• 925-90-6 ethylmagnesium bromide 
• 50-00-0 formaldehyd 

Downstream Products

• 186586-56-1 (2-hydroxy-5-methylsulfanylbenzyl)(2-pyridylmethyl)amine 
• 1111201-28-5 C₈H₉NO₂S 
• 1191271-10-9 2-allyloxy-5-methylsulfanyl-benzaldehyde 
• 115661-22-8 2-cyano-4-methylthiophenol 
• 1672665-49-4 (S)-3-((2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5- fluorobenzonitrile 

Relevant articles and documents

HIF-2α INHIBITORS FOR TREATING IRON OVERLOAD DISORDERS

The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating iron overload disorders. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and reduced liver iron accumulation and serum iron parameters in both prophylactic and treatment mouse models.

Facile one-pot transformation of phenols into o-cyanophenols

The treatment of phenols with paraformaldehyde in the presence of MgCl2 and Et3N in THF at 80 C, followed by reaction with molecular iodine and aq. ammonia at room temperature provided the corresponding o-cyanophenols in moderate to good yields. The present reaction is a one-pot transformation of phenols into o-cyanophenols using much less expensive reagents than are typically used; the reaction is free of both transition-metals and cyanide. The utility of this reaction was highlighted during our preparation of Febuxostat from p-bromophenol.

N-heterocyclic carbene-catalyzed hydroacylation of unactivated double bonds

(Chemical Equation Presented) An intramolecular N-heterocyclic carbene (NHC)-catalyzed hydroacylation of unactivated double bonds is reported. Systematic variation of the catalyst structure revealed an N- mesitylthiazolylidene annulated with a seven-membered ring to be especially reactive. This NHC enables a unique C-C bond-forming reaction to afford substituted chroman-4-ones in moderate to excellent yields, even ones containing all-carbon quaternary centers.