67875-55-2

Basic information

• Product Name: Disiloxane, 1,3-bis(1,1-dimethylethyl)-1,1,3,3-tetramethyl-
• Synonyms: Disiloxane, 1,3-bis(1,1-dimethylethyl)-1,1,3,3-tetramethyl-;1,3-DI-TERT-BUTYL-1,1,3,3-TETRAMETHYLDISILOXANE;tert-butyl-[tert-butyl(dimethyl)silyl]oxy-dimethylsilane
• CAS NO: 67875-55-2
• Molecular Formula: C₁₂H₃₀OSi₂
• Molecular Weight: 246.537
• Mol File: 67875-55-2.mol

Chemical Properties

• Boiling Point: 191-193 °C
• Appearance: /
• Density: 0.809±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Disiloxane, 1,3-bis(1,1-dimethylethyl)-1,1,3,3-tetramethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Disiloxane, 1,3-bis(1,1-dimethylethyl)-1,1,3,3-tetramethyl-(67875-55-2)
• EPA Substance Registry System: Disiloxane, 1,3-bis(1,1-dimethylethyl)-1,1,3,3-tetramethyl-(67875-55-2)

Safety Data

• Hazardous Substances Data: 67875-55-2(Hazardous Substances Data)

Usage

General Description

Disiloxane, 1,3-bis(1,1-dimethylethyl)-1,1,3,3-tetramethyl- is a chemical compound that belongs to the class of siloxanes, which are silicon-oxygen compounds commonly used in the production of silicones. This particular compound has a molecular formula of C12H32O2Si2 and a molecular weight of 264.56 g/mol. It is often used as a solvent and in the production of various silicone-based products, including adhesives, sealants, and coatings. It is known for its low viscosity and volatility, making it a useful component in many industrial and commercial applications. However, it is important to handle this chemical with care, as it may pose health and environmental risks if not used properly.

Upstream product

• 62790-77-6 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxybenzene 
• 2524-49-4 3-butene-1-amine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 288-32-4 1H-imidazole 
• 29681-57-0 tert-butyldimethylsilane 
• 156-38-7 4-hydroxyphenylacetate 
• 53172-91-1 (benzyloxy)(tert-butyl)dimethylsilane 
• 2416-94-6 2,3,6-trimethylphenol 

Downstream Products

• 143258-65-5 1-(2-ethyl-6,8-dimethylimidazo[1,2-b]pyridazin-3-yl)-1-(4-hydroxyphenyl)methanol 

Relevant articles and documents

NOVEL LIPIDS AND NANOPARTICLE COMPOSITIONS THEREOF

Provided herein are lipids having the Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, a, and b are as defined herein. Also provided herein are lipid nanoparticle (LNP) compositions comprising lipid having the Formula (I) and a capsid-free, non-viral vector (e.g., ceDNA). In one aspect of any of the aspects or embodiments herein, these LNPs can be used to deliver a capsid-free, non-viral DNA vector to a target site of interest (e.g., cell, tissue, organ, and the like).

Hafnium Triflate as a Highly Potent Catalyst for Regio- and Chemoselective Deprotection of Silyl Ethers

As a Group IVB transition metal Lewis acid, hafnium triflate [Hf(OTf) 4 ] exhibited exceptionally high potency in desilylations. Since the amounts of Hf(OTf) 4 required for the deprotection of 1°, 2°, 3° alkyl and aryl tert -butyldimethylsilyl (TBS) ethers are significantly different, ranging from 0.05 mol% to 3 mol%, regioselective deprotection of TBS could be easily implemented. Moreover, chemoselective cleavage of different silyl ethers or removal of TBS in the presence of most hydroxyl protecting groups was also accomplished. NMR analyses of silyl products from TBS deprotection indicated that Hf(OTf) 4 -catalyzed desilylation may proceed via different mechanisms, depending on the solvent used.

Highly Functionalized Tricyclic Oxazinanones via Pairwise Oxidative Dearomatization and N-Hydroxycarbamate Dehydrogenation: Molecular Diversity Inspired by Tetrodotoxin

Benzenoids in principle represent attractive and abundant starting materials for the preparation of substituted cyclohexanes; however, the synthetic tools available for overcoming the considerable aromatic energies inherent to these building blocks limit the available product types. In this paper, we demonstrate access to heretofore unknown heterotricyclic structures by leveraging oxidative dearomatization of 2-hydroxymethyl phenols with concurrent N-hydroxycarbamate dehydrogenation using a common oxidant. The pairwise-generated, mutually reactive species then participate in a second stage acylnitroso Diels-Alder cycloaddition. The reaction chemistry of the derived [2.2.2]-oxazabicycles, bearing four orthogonal functional groups and three stereogenic centers, is shown to yield considerable diversity in downstream products. The methodology allows for the expeditious synthesis of a functionalized intermediate bearing structural and stereochemical features in common with the complex alkaloid tetrodotoxin.

Hydrogenation and Hydrosilylation of Nitrous Oxide Homogeneously Catalyzed by a Metal Complex

Due to its significant contribution to stratospheric ozone depletion and its potent greenhouse effect, nitrous oxide has stimulated much research interest regarding its reactivity modes and its transformations, which can lead to its abatement. We report the homogeneously catalyzed reaction of nitrous oxide (N2O) with H2. The reaction is catalyzed by a PNP pincer ruthenium complex, generating efficiently only dinitrogen and water, under mild conditions, thus providing a green, mild methodology for removal of nitrous oxide. The reaction proceeds through a sequence of dihydrogen activation, "O"-atom transfer, and dehydration, in which metal-ligand cooperation plays a central role. This approach was further developed to catalytic O-transfer from N2O to Si-H bonds.

Supported gold nanoparticle catalyst for the selective oxidation of silanes to silanols in water

Hydroxyapatite-supported gold nanoparticles (AuHAP) can act as highly efficient and reusable catalysts for the oxidation of diverse silanes into silanols in water; this is the first catalytic methodology for the selective synthesis of aliphatic silanols using water under organic-solvent-free conditions.

Genenation of 1-azapentadienyl anion from N-(tert-butyldimethylsilyl)-3-buten-1-amine

N-(tert-Butyldimethylsilyl)-3-buten-1-amine undergoes allylic deprotonation at the 2-position when exposed to 2 equiv of nBuLi in THF. This allylic anion undergoes lithium hydride elimination to generate a 1-azapentadienyl anion. The anion is generated cleanly and completely.

Conversion of 7-Methoxy-3,4-dihydro-2H-1-benzopyran-2-one into the corresponding dimethyl ortho ester

7-Methoxy-3,4-dihydro-2H-1-benzopyran-2-one 2 was converted into 3-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-N-methyl-N-phenylpropanamide 25 and reaction of this with methyl trifluoromethanesulfonate, followed by reaction with sodium methoxide, gave 2,2,7-trimethoxy-2H- 1-benzopyran 1a in 55% overall yield from 25. A similar methylation/methoxide sequence using 3-(2'-benzyloxy-4-methoxyphenyl)-N-methyl-N-phenylpropanamide 18 gave a mixture which contained trimethyl 3-(2'-benzyloxy-4'-methoxyphenyl)orthopropanoate 20a and reaction of this mixture with a solution of sodium in tert-butanol gave a product in which 2,2,7-trimethoxy-2H-1-benzopyran 1a was detected, but not isolable.

9-Substituted carbacyclin analogs

Novel compounds of the following general formula: STR1

Composition and process

The present specification provides novel analogs of carbacyclin (CBA2), 6a-carba-prostacyclin (6a-carba-PGI2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet antiaggregatory agents. Specifically the novel chemical analogs of CBA2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA2 analogs.