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Relevant academic research and scientific papers

Novel spiro-1,2,4-trioxanes

The present invention relates to spiro 1,2,4-trioxanes of general formula 4. This invention more particularly relates to a process for the preparation of a series of spiro 1,2,4-trioxanes. Wherein, Ar represents aryl groups such as phenyl, 4-biphenyl, 4-c

SPIRO-1,2,4-TRIOXANES AS ANTIMALARIAL AGENTS

The present invention provides novel spiro trioxane series of general Formula (4). This invention also provides a process for the preparation of novel spiro trioxane series. These novel spiro-trioxane cmpounds useful as anti-malarial agents.

Orally active 1,2,4-trioxanes: Synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxaspiro[5.5]undecanes against multi-drug-resistant Plasmodium yoelii nigeriensis in mice

Using easily accessible keto-trioxanes 7a-g as the starting materials, a series of new variously functionalized 1,2,4-trioxanes 10-36 have been prepared and evaluated for antimalarial activity against multi-drug-resistant Plasmodium yoelii nigeriensis in

AMINO-FUNCTIONALIZED 1,2,4-TRIOXANES USEFUL AS ANTIMALARIAL AGENTS AND PROCESS FOR PREPARATION THEREOF

The present invention relates to a novel series of antimalarial amino functionalized 1,2,4-trioxane analogues of formula 4 wherein Ar represents aryl groups such as phenyl, 4-biphenyl, 4-chlorophenyl, 4-methoxyphenyl, 4-methylphenyl and R represents pheny

AMINO-FUNCTIONALIZED 1,2,4-TRIOXANES USEFUL AS ANTI-MALARIAL AGENTS AND PROCESS FOR PREPARATION THEREOF

The present invention relates to a novel series of antimalarial amino functionalized 1,2,4-trioxane analogues of formula (4): wherein Ar represents aryl groups such as phenyl, 4-biphenyl, 4-chlorophenyl, 4-methoxyphenyl, 4-methylphenyl and R represents ph

Orally active amino functionalized antimalarial 1,2,4-trioxanes

Using readily available trioxanes 6a-b, a new series of amino functionalized 1,2,4-trioxanes 8a-e and 9a-e have been prepared and evaluated for antimalarial activity against multi-drug resistant Plasmodium yoelii in Swiss mice model. Several of these nove

Synthesis and antimalarial activity of a new series of trioxaquines

Trioxanes 8a-b, easily accessible in two steps from allylic alcohol 6a-b, on reductive amination with 4-aminoquinolines 4a-c furnish a new series of trioxaquines 9a-b, 10a-b, 11a-b in 32-77% yields. Dicitrate salts of these trioxaquines have been evaluate