679002-22-3Relevant academic research and scientific papers
Construction of Azacycles Based on Endo-Mode Cyclization of Allenes
Mukai, Chisato,Kobayashi, Minoru,Kubota, Shoko,Takahashi, Yukie,Kitagaki, Shinji
, p. 2128 - 2136 (2004)
A new procedure for constructing monocyclic five- and six-membered azacycles by the endo-mode ring-closing reaction of allenylazido derivatives under neutral conditions has been developed. The azabicyclo[m.n.0] compounds were prepared by applying this newly developed procedure. The seven-membered azacycle was prepared when the allene possessing an unsubstituted carboxyl amido functionality was submitted to the basic conditions. In addition, indole and quinoline skeletons were synthesized using this procedure.
