67910-98-9 Usage
Uses
Used in Neurochemistry Research:
4-Aminobutyric-2,2-D2 acid is used as an internal standard for the quantification of γ-aminobutyric acid (GABA) in human plasma and cerebrospinal fluid. This application is crucial for accurate measurement and analysis of GABA levels, which can provide insights into various neurological conditions and disorders associated with GABAergic neurotransmission.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Aminobutyric-2,2-D2 acid can be used as a reference compound for the development and validation of analytical methods for GABA quantification. This ensures the reliability and accuracy of GABA measurements in drug discovery and development processes, ultimately contributing to the advancement of treatments for neurological disorders.
Used in Clinical Diagnostics:
4-Aminobutyric-2,2-D2 acid can be employed as a calibration standard in clinical diagnostic assays for the measurement of GABA levels in patient samples. This helps in the diagnosis and monitoring of neurological conditions, as well as in the assessment of treatment efficacy for patients undergoing therapy for GABA-related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 67910-98-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,9,1 and 0 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 67910-98:
(7*6)+(6*7)+(5*9)+(4*1)+(3*0)+(2*9)+(1*8)=159
159 % 10 = 9
So 67910-98-9 is a valid CAS Registry Number.
67910-98-9Relevant academic research and scientific papers
Synthesis of the neurotransmitter 4-aminobutanoic acid (GABA) from diethyl cyanomalonate
Cook, Matthew C.,Witherell, Ross D.,White, Robert L.
experimental part, p. 9 - 13 (2011/01/03)
GABA was synthesized by deethoxycarbonylation, ester hydrolysis and nitrile reduction of a highly functionalized intermediate obtained by alkylation of diethyl cyanomalonate with ethyl bromoacetate. By judicious employment of D 2O or NaBD4 in one of the three functional group transformation steps, deuterium was selectively introduced into each of the three possible sites in GABA.
