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1-Acetyl-4-(4-hydroxyphenyl)piperazine side chain of Ketoconazole is a component of the antifungal medication Ketoconazole. It is a synthetic, imidazole-derived molecule that plays a significant role in the antifungal activity of the drug. This side chain contributes to blocking the fungal cytochrome P450 enzyme 14α-demethylase, which is crucial for the synthesis of ergosterol, a vital component of the fungal cell membrane. The introduction of an acetyl group to the 4-(4-hydroxyphenyl)piperazine structure can potentially influence the potency and pharmacokinetic properties of the drug, although the exact effects may vary depending on the specific modifications made.

67914-99-2

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67914-99-2 Usage

Uses

Used in Pharmaceutical Industry:
1-Acetyl-4-(4-hydroxyphenyl)piperazine side chain of Ketoconazole is used as an active pharmaceutical ingredient for the development of antifungal medications. It is employed for its ability to inhibit the production of ergosterol, a key component of the fungal cell membrane, thereby destabilizing the membrane and leading to the death of the fungi.
Used in Antifungal Treatments:
1-Acetyl-4-(4-hydroxyphenyl)piperazine side chain of Ketoconazole is used as a therapeutic agent for treating various fungal infections. Its role in blocking the fungal cytochrome P450 enzyme 14α-demethylase makes it an effective component in combating fungal pathogens and preventing their proliferation.
Used in Drug Development Research:
1-Acetyl-4-(4-hydroxyphenyl)piperazine side chain of Ketoconazole is used as a research compound for studying the effects of structural modifications on the potency and pharmacokinetic properties of antifungal drugs. This research can lead to the development of more effective and targeted antifungal medications with improved efficacy and reduced side effects.

Check Digit Verification of cas no

The CAS Registry Mumber 67914-99-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,9,1 and 4 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 67914-99:
(7*6)+(6*7)+(5*9)+(4*1)+(3*4)+(2*9)+(1*9)=172
172 % 10 = 2
So 67914-99-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H18N2O3/c1-2-18-13(17)15-9-7-14(8-10-15)11-3-5-12(16)6-4-11/h3-6,16H,2,7-10H2,1H3

67914-99-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(4-hydroxy-phenyl)-piperazine-1-carboxylic acid ethyl ester

1.2 Other means of identification

Product number -
Other names 4-(4-Hydroxyphenyl)-1-piperazinecarboxylic acid ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:67914-99-2 SDS

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