67916-54-5

Basic information

• Product Name: bis(4-methoxyphenyl)(pyridin-2-yl)methanol
• CAS NO: 67916-54-5
• Molecular Formula: C₂₀H₁₉NO₃
• Molecular Weight: 321.3698
• Mol File: 67916-54-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 498.1°C at 760 mmHg
• Flash Point: 255.1°C
• Density: 1.183g/cm³
• Vapor Pressure: 9.67E-11mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: bis(4-methoxyphenyl)(pyridin-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: bis(4-methoxyphenyl)(pyridin-2-yl)methanol(67916-54-5)
• EPA Substance Registry System: bis(4-methoxyphenyl)(pyridin-2-yl)methanol(67916-54-5)

Safety Data

• Hazardous Substances Data: 67916-54-5(Hazardous Substances Data)

Usage

General Description

Bis(4-methoxyphenyl)(pyridin-2-yl)methanol is a chemical compound with the molecular formula C23H21NO3. It is a white to off-white solid that is insoluble in water but soluble in organic solvents. bis(4-methoxyphenyl)(pyridin-2-yl)methanol is often used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It has been found to exhibit anti-inflammatory and anti-cancer properties in certain studies, making it a potentially valuable compound for medicinal chemistry research. Additionally, it has been investigated for its potential use in organic light-emitting diodes (OLEDs) and other optoelectronic applications due to its unique molecular structure and properties.

Upstream product

• 17624-36-1 2-pyridyllithium 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 2524-52-9 ethyl-2-picolinate 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 67916-64-7 7-methoxy-10-(4-methoxyphenyl)pyrido[1,2-a]indole 
• 102237-74-1 4-(bis(4-methoxyphenyl)methyl)pyridine 
• 603-41-8 4,4'-(2-pyridylmethylene)diphenol 

Relevant articles and documents

A process for preparing sodium new method (by machine translation)

The invention relates to a method for preparing (V) indicated by the sodium of the method, the method comprises the following steps: (a) in formula (I) indicated by the 2 - picolinic ester as the starting material, as shown in formula (II) of 4 - halogenated phenyl ether in the formula (III) Grignard reaction indicated by the 4', 4" - dialkoxy diphenyl - (2 - pyridine) - methanol (compound III). (B) 4 ', 4 "- dialkoxy diphenyl - (2 - pyridine) - methanol (compound III) in the Lewis acid under the action of removing a water molecule and alkoxy alkyl, formula (IV) as shown by a 4', 4" - dihydroxy phenyl - (2 - pyridine) - methane (compound IV). (C) 4', 4" - dihydroxy phenyl - (2 - pyridine) - methane with chlorosulfuric acid in sulfuric acid esterification reaction, sodium hydroxide after treatment, to obtain crude sodium, by recrystallization to obtain high-purity sodium (compound V). The present invention provides a kind of existing technology with the different sodium new preparation method, the method is simple in operation, the atom economy is high, is suitable for industrial production. (by machine translation)

Iron-catalyzed C-H bond functionalization for the exclusive synthesis of pyrido[1,2-a]indoles or triarylmethanols

The efficient and selective iron-catalyzed C-H activation of 2-benzhydrylpyridine derivatives was employed for the preparation of pyrido[1,2-a]indoles through an intramolecular C-H amination reaction. In the presence of molecular oxygen as the sole oxidant, the same 2-benzhydrylpyridines were also used for the synthesis of the corresponding tertiary alcohols. In these approaches, the iron catalyst was used to selectively activate the C(sp2)-H bond of 2-benzhydrylpyridine, in the case of the intramolecular ring-closing C-H amination reaction in which the pyridine nitrogen atom was a directing group as well as a nucleophile, and the C(sp3)-H bond of the same compound, in the case of the oxidation reaction to give the corresponding triaryl carbinol.