679394-73-1Relevant academic research and scientific papers
Synthesis of benzimidazole thiazolinone derivatives under microwave irradiation
Hu, Jun,Yu, Peng,Zhou, Taoyu,Xu, Yanhua
, p. 672 - 673,2 (2011)
Organic compounds containing the thiazolinone ring are of increasing interest due to their bactericidal, pesticidal, anticonvulsant, antiinflammatory, antithyroidal and antimicrobial activities. A rapid microwave-assisted synthesis thiazolinone derivatives is described. The 3-(1H-benzo[d]imidazol-2-yl)-2-substituted phenyl thiazolidin-4-one were identified by IR, 1H NMR, elemental analyses. The target compounds were performed in a shorter reaction time compared to conventional heating methods.
Asymmetric Carbene-Catalyzed Oxidation of Functionalized Aldimines as 1,4-Dipoles
Wang, Guanjie,Zhang, Qiao-Chu,Wei, Chenlong,Zhang, Ye,Zhang, Linxue,Huang, Juhui,Wei, Donghui,Fu, Zhenqian,Huang, Wei
supporting information, p. 7913 - 7919 (2021/03/03)
The use of functionalized aldimines has been demonstrated as newly structural 1,4-dipole precursors under carbene catalysis. More importantly, enantiodivergent organocatalysis has been successfully developed using carbene catalysts with the same absolute configuration, leading to both (R)- and (S)- enantiomers of six-membered heterocycles with quaternary carbon centers. This strategy features a broad substrate scope, mild reaction conditions, and good enantiomeric ratio. DFT calculation results indicated that hydrogen bond C?H???F interactions between the catalyst and substrate are the key factors for controlling and even switching the enantioselectivity. These new 1,4-dipoles can also react with isatin and its imines under carbene catalysis, allowing for access to the spiro oxindoles with excellent enantiomeric ratios.
Synthesis and antiproliferative activity in vitro of 2-aminobenzimidazole derivatives
Nawrocka, Wanda,Sztuba, Barbara,Kowalska, Maria W.,Liszkiewicz, Hanna,Wietrzyk, Joanna,Nasulewicz, Anna,Pelczynska, Marzena,Opolski, Adam
, p. 83 - 91 (2007/10/03)
A novel series of Schiff bases 1-11, the derivatives of 2-aminobenzimidazole and substituted aromatic aldehydes, has been synthesised. Compounds 1-11 reduced by NaBH4 formed 2-benzylaminobenzimidazoles 12-21. 2-(o-Bromobenzylamino)benzimidazole (15) acylated by cinnamoyl chloride gave 2-(o-bromobenzylamino)-1-cinnamoylbenzimidazole (22). Long heating of 15 and 19 with p-nitrocinnamoyl or cinnamoyl chloride led to the formation of pyrimido[1,2-a]benzimidazol-4-ones 23 and 24. The structures of 1-24 were identified by the results of elemental analysis and their IR, 1H NMR and MS spectra. Among the compounds 1-24 evaluated for their antiproliferative activity in vitro, 16, 19, 20 and 22 exhibited cytotoxic activity against the cells of human cancer cell lines, namely SW707 (rectal), HCV29T (bladder), A549 (lung) and T47D (breast cancer).
