679404-36-5Relevant academic research and scientific papers
Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization
Sanders, William J.,Nienaber, Vicki L.,Lerner, Claude G.,McCall, J. Owen,Merrick, Sean M.,Swanson, Susan J.,Harlan, John E.,Stoll, Vincent S.,Stamper, Geoffrey F.,Betz, Stephen F.,Condroski, Kevin R.,Meadows, Robert P.,Severin, Jean M.,Walter, Karl A.,Magdalinos, Peter,Jakob, Clarissa G.,Wagner, Rolf,Beutel, Bruce A.
, p. 1709 - 1718 (2004)
Potent inhibitors of 7,8-dihydroneopterin aldolase (DHNA; EC 4.1.2.25) have been discovered using CrystaLEAD X-ray crystallographic high-throughput screening followed by structure-directed optimization. Screening of a 10 000 compound random library provid
