679412-08-9Relevant academic research and scientific papers
De novo asymmetric synthesis of All-d-, All-l-, and d-/l-oligosaccharides using atom-less protecting groups
Babu, Ravula Satheesh,Chen, Qian,Kang, Sang-Woo,Zhou, Maoquan,O'Doherty, George A.
supporting information; experimental part, p. 11952 - 11955 (2012/09/07)
Oligosaccharide synthesis is hindered by the need for multiple steps as well as numerous selective protections and deprotections. Herein we report a highly efficient de novo route to various oligosaccharide motifs, of use for biological and medicinal structure activity studies. The key to the overall efficiency is the judicious use of asymmetric catalysis and synthetic design. These green principles include the bidirectional use of highly stereoselective catalysis (Pd(0)-catalyzed glycosylation/post-glycosylation). In addition, the chemoselective use of C-C and C-O π-bond functionality, as atom-less protecting groups as well as an anomeric directing group (via a Pd-π-allyl), highlights the atom-economical aspects of the route to a divergent set of natural and unnatural oligosaccharides (i.e., various d-/l-diastereomers of oligosaccharides as well as deoxysugars which lack C-2 anomeric directing groups). For example, in only 12 steps, the construction of a highly branched heptasaccharide with 35 stereocenters was accomplished from an achiral acylfuran.
De Novo Synthesis of Oligosaccharades Using a Palladium-Catalyzed Glycosylation Reaction
Babu, Ravula Satheesh,Zhou, Maoquan,O'Doherty, George A.
, p. 3428 - 3429 (2007/10/03)
The natural all d- and/or unnatural all l-1,4- and 1,6-oligosaccharides were synthesized from furan alcohols using a palladium-catalyzed glycosylation reaction. The 1,4- and 1,6-α-manno-disaccharides were achieved in seven total steps starting from chiral furan alcohols. Similarly, 1,4- and 1,6-α-manno-trisaccharides were also synthesized in nine total steps. Key to the overall efficiency of this process was the use of highly diastereoselective palladium-catalyzed glycosylations, reductions, and dihydroxylations. Copyright
