679426-53-0

Basic information

• Product Name: C₃₀H₃₂Cl₂N₄O₆
• CAS NO: 679426-53-0
• Molecular Weight: 615.513
• Mol File: 679426-53-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₀H₃₂Cl₂N₄O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₃₂Cl₂N₄O₆(679426-53-0)
• EPA Substance Registry System: C₃₀H₃₂Cl₂N₄O₆(679426-53-0)

Safety Data

• Hazardous Substances Data: 679426-53-0(Hazardous Substances Data)

Upstream product

• 280771-82-6 N-(5-chloropyridin-2-yl)-5-chloro-2-nitrobenzamide 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 
• 51779-32-9 iminodicarboxylic acid di-tert-butyl ester 
• 358661-80-0 5-Chloro-2-(4-chloromethyl-benzoylamino)-N-(5-chloro-pyridin-2-yl)-benzamide 

Relevant articles and documents

Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity

Compound 2 containing an aminomethylbenzoyl moiety as the S4 binding motif was synthesized in order to modulate hydrophlicity of anthranilamide-based factor Xa inhibitors with substituted biphenyl P4 groups. Structure-activity relationship studies around 2 have led to a series of potent factor Xa inhibitors which are highly active in the human plasma-based thrombin generation assay with 2XTG values less than 1 μM. Compound 55 shows strong antithrombotic activity in our rabbit deep vein thrombosis model, and also exhibits good oral bioavailability and a long half life in rats.