67945-75-9Relevant academic research and scientific papers
Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy
Slee, Deborah H.,Zhang, Xiaohu,Moorjani, Manisha,Lin, Emily,Lanier, Marion C.,Chen, Yongsheng,Rueter, Jaimie K.,Lechner, Sandra M.,Markison, Stacy,Malany, Siobhan,Joswig, Tanya,Santos, Mark,Gross, Raymond S.,Williams, John P.,Castro-Palomino, Julio C.,Crespo, María I.,Prat, Maria,Gual, Silvia,Díaz, José-Luis,Wen, Jenny,O'Brien, Zhihong,Saunders, John
, p. 400 - 406 (2008/12/20)
Potent adenosine hA2A receptor antagonists are often accompanied by poor aqueous solubility, which presents issues for drug development. Herein we describe the early exploration of the structure-activity relationships of a lead pyrimidin-4-yl a
2, 6 BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS
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Page/Page column 71, (2010/02/12)
4-Aminopyrimidine derivatives of formula (I) FORMULA heteroaryl groups, including pharmaceutically acceptable salts thereof, wherein R1 and R2 are adenosine A2A receptor antagonists useful in the treatment of movement disorders such as Parkinson's disease.
