67945-93-1

Upstream product

• 122-78-1 phenylacetaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 3695-92-9 (Z)-3-(4-chlorophenyl)-2-phenylacrylonitrile 
• 140-29-4 phenylacetonitrile 
• 7466-99-1 (E)-3-(4-chlorophenyl)-2-phenylprop-2-enoic acid 
• 103-82-2 phenylacetic acid 
• 588-72-7 [(E)-2-bromoethenyl]benzene 

Downstream Products

• 1608154-80-8 3-(4-chlorophenyl)-2,3-dihydro-1-methyl-4-phenyl-1H-pyrrole 
• 1608154-81-9 8-chloro-2,3-dihydro-2-methyl-4-phenyl-1H-2-benzazepine 
• 67946-18-3 6-(4-chloro-phenyl)-5-phenyl-2-p-tolyl-3,6-dihydro-2H-[1,2]oxazine 
• 67946-16-1 2,6-bis-(4-chloro-phenyl)-5-phenyl-3,6-dihydro-2H-[1,2]oxazine 
• 67946-19-4 6-(4-chloro-phenyl)-2-(4-methoxy-phenyl)-5-phenyl-3,6-dihydro-2H-[1,2]oxazine 
• 67946-17-2 6-(4-chloro-phenyl)-2,5-diphenyl-3,6-dihydro-2H-[1,2]oxazine 
• 67945-97-5 1-chloro-4-((Z)-2-phenyl-buta-1,3-dienyl)-benzene 

Relevant academic research and scientific papers

INHIBITORS OF THE N-TERMINAL DOMAIN OF THE ANDROGEN RECEPTOR

The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

Synthesis of β-Amino Diaryldienones Using the Mannich Reaction

The Mannich reaction has been used for decades to prepare many pharmaceutically important molecules. Here, using a "double-Mannich-β-elimination" synthetic sequence, we report the synthesis and the characterization details of a novel class of β-amino diaryldienones with prominent antiprostate cancer activity. Through these studies, we correct an erroneous structure in the current literature, present a discussion of the stereochemical outcome of a new reaction, and probe the mechanism(s) of byproduct formation through isotopic studies.

INHIBITORS OF THE N-TERMINAL DOMAIN OF THE ANDROGEN RECEPTOR

The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

An investigation of the scope of the 1,7-electrocyclization of α,β:γ,δ-conjugated azomethine ylides

Substituents on the diene component have little influence on the periselectivity of the cyclizations of α,β:γ,δ-conjugated azomethine ylides, with 1,7-electrocyclizations predominating. In some cases, subtle changes to these substituents can, however, influence the product formed, through their effect on the relative energies of the transition states for the 1,5- (6π) and 1,7-electrocyclization (8π) processes. The most striking changes in periselectivity occur for phenylethenyl-substituted azomethine ylides 3d-f, which can give either a pyrroline 4d,f or dihydrobenzazepine 6e, depending upon the alkene configuration.

Ruthenium-catalyzed aldehyde functionality reshuffle: Selective synthesis of E-2-arylcinnamaldehydes from E-β-bromostyrenes and aryl aldehydes

A new concept for highly selective synthesis of E-2-arylcinnamaldehydes has been developed via a formal arylformylation of E-β-bromostyrenes with readily available aryl aldehydes. This strategy involves an overall reshuffle of the aldehyde functionality with a loss of hydrogen bromide.