67947-62-0

Upstream product

• 188290-36-0 thiophene 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 63212-32-8 1-ethyl-2-isocyanobenzene 
• 81745-84-8 2-thienylzinc chloride 
• 824-94-2 p-methoxybenzyl chloride 
• 267884-96-8 N-methoxy-2-(4-methoxyphenyl)-N-methylethanamide 
• 88-15-3 2-Acetylthiophene 
• 623-12-1 4-chloromethoxybenzene 

Downstream Products

• 108876-05-7 2-(4-methoxy-phenyl)-1-[2]thienyl-ethylamine 
• 80154-91-2 Ethyl-[2-(4-methoxy-phenyl)-1-thiophen-2-yl-ethyl]-amine; hydrochloride 
• 80154-90-1 2-(4-methoxy-phenyl)-1-[2]thienyl-ethylamine; hydrochloride 
• 94843-23-9 5-(4-anisyl)-4-(thiophen-2-yl)-1,2,3-thiadiazole 
• 628322-09-8 N-[2-(4-methoxy-phenyl)-1-thiophen-2-yl-ethylidene]-N'-phenyl-hydrazine 

Relevant academic research and scientific papers

Palladium-catalyzed secondary benzylic imidoylative reactions

Reported herein is a palladium-catalyzed secondary benzylic imidoylative Negishi reaction leveraging the sterically bulky aromatic isocyanides as the imine source. This method allows the facile access of alkyl-, (hetero)aryl-, and alkynylzinc reagents to afford various α-substituted phenylacetone products under mild acidic hydrolysis, which are ubiquitous motifs in many pharmaceuticals and biologically active compounds. The diastereoselective reduction of imine can be accomplished to provide the expedient conversion of secondary benzylic halide into α-substituted phenethylamine derivatives with high atom economy.

NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME

The present invention provides novel transition-metal precatalysts that are useful in preparing active coupling catalysts. In certain embodiments, the precatalysts of the invention are air-stable and moisture-stable. The present invention further provides methods of making and using the precatalysts of the invention.

Design of a versatile and improved precatalyst scaffold for palladium-catalyzed cross-coupling: (η3-1-tBu-indenyl)2(μ-Cl)2Pd2

We describe the development of (η3-1-tBu-indenyl)2(μ-Cl)2Pd2, a versatile precatalyst scaffold for Pd-catalyzed cross-coupling. Our new system is more active than commercially available (η3-cinnamyl)2(μ-Cl)2Pd2 and is compatible with a range of NHC and phosphine ligands. Precatalysts of the type (η3-1-tBu-indenyl)Pd(Cl)(L) can either be isolated through the reaction of (η3-1-tBu-indenyl)2(μ-Cl)2Pd2 with the appropriate ligand or generated in situ, which offers advantages for ligand screening. We show that the (η3-1-tBu-indenyl)2(μ-Cl)2Pd2 scaffold generates highly active systems for a number of challenging cross-coupling reactions. The reason for the improved catalytic activity of systems generated from the (η3-1-tBu-indenyl)2(μ-Cl)2Pd2 scaffold compared to (η3-cinnamyl)2(μ-Cl)2Pd2 is that inactive PdI dimers are not formed during catalysis.

Selective monoarylation of acetate esters and aryl methyl ketones using aryl chlorides

Simple, efficient procedures for the monoarylation of acetate esters and aryl methyl ketones using aryl chlorides are presented. Previously, no general method was available to ensure the highly selective monoarylation of these classes of substrates using

Indole compounds and their use as estrogen agonists/antagonists

This invention relates to compounds, in particular indoles, that are useful as estrogen agonists and antagonists and pharmaceutical uses thereof. The present invention also relates to indoles that are selective for the ERβ receptor and pharmaceutical uses

1,2,3-thiadiazole compounds, compositions and method of anti-thrombotic treatment

Novel 1,2,3-thiadiazole compounds, new and old 1,2,3-thiadiazole compositions and method of anti-thrombotic treatment are systemically administered to a human or animal.

Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones

Antiinflammatory 4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones, such as, 4-(4-fluorophenyl)-2-(1,1,2,2-tetrafluoroethylsulfonyl)-5-(2-thienyl)-1H-imidazole, useful for treating arthritis and related diseases.