67959-55-1Relevant academic research and scientific papers
Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs)
Gorsuch, Stephen,Bavetsias, Vassilios,Rowlands, Martin G.,Aherne, G. Wynne,Workman, Paul,Jarman, Michael,McDonald, Edward
experimental part, p. 467 - 474 (2009/07/25)
High-throughput screening led to the identification of isothiazolones 1 and 2 as inhibitors of histone acetyltransferase (HAT) with IC50s of 3 μM and 5 μM, respectively. Analogues of these hit compounds with variations of the N-phenyl group, and with vari
