67960-33-2

Upstream product

• 112398-75-1 5-chloro-1-methyl-1H-indole 
• 479675-59-7 (E)-1-phenylethan-1-one O-perfluorobenzoyl oxime 
• 75681-32-2 2-((4-chlorophenyl)(methyl)amino)-1-phenylethanone 
• 62082-49-9 1-(p-chlorophenyl)-3-phenylazetidin-3-ol 
• 70-11-1 α-bromoacetophenone 
• 932-96-7 N-methyl(p-chloroaniline) 

Relevant academic research and scientific papers

NH4PF6-promoted cyclodehydration of α-amino carbonyl compounds: Efficient synthesis of pyrrolo[3,2,1-ij]quinoline and indole derivatives

NH4PF6 is an inexpensive, safe, and low-toxicity inorganic salt; it was found to promote the cyclodehydration of α-amino carbonyl compounds in the absence of metal reagents. This simple cyclodehydration strategy enables highly atom-e

C3-Arylation of indoles with aryl ketonesviaC-C/C-H activations

C3-Arylation of indoles with aryl ketones is accomplishedviapalladium-catalyzed ligand-promoted Ar-C(O) cleavage and subsequent C-H arylation of indole. Various (hetero)aryl ketones are compatible in this reaction, affording the corresponding 3-arylindoles in moderate to good yields. Further introduction of an indole moiety into the natural products desoxyestrone and evodiamine demonstrate the synthetic utility of this protocol.

HFIP-promoted Bischler indole synthesis under microwave irradiation

1,1,1,3,3,3-Hexafluoropropan-2-ol (HFIP) was found to be effective for the Bischler indole synthesis under microwave irradiation in the absence of a metal catalyst. Under the catalysis of HFIP, a wide range of α-amino arylacetones were successfully transf

Construction of indole skeletons by sequential actions of sunlight and rhodium on α-aminoacetophenones

Indole skeletons were constructed from 2-(N-aryl-N-methylamino) acetophenones by the sequential actions of sunlight and a rhodium catalyst. This method presents an example of the direct use of sunlight in organic synthesis.