67967-14-0

Basic information

• Product Name: 5-BROMO-[1,7]NAPHTHYRIDIN-8-OL
• Synonyms: 5-Bromo-1,7-naphthyridin-8(7H)-one;5-BroMo-8-hydroxy-1,7-naphthyridine;5-BROMO-[1,7]NAPHTHYRIDIN-8-OL
• CAS NO: 67967-14-0
• Molecular Formula: C₈H₅BrN₂O
• Molecular Weight: 225.04
• Mol File: 67967-14-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 333-335 °C(Solv: acetic acid (64-19-7); water (7732-18-5))
• Boiling Point: 455.087°C at 760 mmHg
• Flash Point: 229.028°C
• Appearance: /
• Density: 1.806g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.732
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.43±0.40(Predicted)
• CAS DataBase Reference: 5-BROMO-[1,7]NAPHTHYRIDIN-8-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-[1,7]NAPHTHYRIDIN-8-OL(67967-14-0)
• EPA Substance Registry System: 5-BROMO-[1,7]NAPHTHYRIDIN-8-OL(67967-14-0)

Safety Data

• Hazardous Substances Data: 67967-14-0(Hazardous Substances Data)

Usage

General Description

5-Bromo-[1,7]naphthyridin-8-ol is a chemical compound with the molecular formula C11H6BrNO. It is a naphthyridine derivative with a bromine atom and a hydroxyl group attached at specific positions on the naphthyridine ring. 5-BROMO-[1,7]NAPHTHYRIDIN-8-OL has potential applications in the field of medicinal chemistry and drug development, particularly in the synthesis of biologically active molecules and pharmaceuticals. It may also have uses as a research tool for studying biological processes and interactions. The specific properties and potential uses of 5-Bromo-[1,7]naphthyridin-8-ol continue to be studied and explored within the scientific community.

InChI:InChI=1/C8H5BrN2O/c9-6-4-11-8(12)7-5(6)2-1-3-10-7/h1-4H,(H,11,12)

Upstream product

• 67967-11-7 1,7-naphthyridinyl-8(7H)-one 

Downstream Products

• 1616401-75-2 7-benzyl-5-(3,5-dimethylisoxazol-4-yl)-1,7-naphthyridin-8(7H)-one 
• 1616403-11-2 7-benzyl-5-bromo-1,7-naphthyridin-8(7H)-one 
• 1449278-53-8 8-amino-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxylic acid 
• 1449278-52-7 ethyl 8-chloro-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxylate 
• 1449278-51-6 ethyl 2-(3-fluorophenyl)-8-oxo-7H-1,7-naphthyridine-5-carboxylate 
• 1449278-50-5 ethyl 2-(3-fluorophenyl)-8-oxo-7-(2-trimethylsilylethoxymethyl)-1,7-naphthyridine-5-carboxylate 
• 1449276-86-1 8-amino-N-cyclopropyl-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide 
• 1449277-90-0 ethyl 8-amino-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxylate 
• 1449278-77-6 C₃₃H₃₉FN₆O₅ 
• 1449278-74-3 C₂₄H₂₅FIN₃O₄ 
• 1449278-73-2 C₁₄H₉FIN₃ 
• 1449278-71-0 8-amino-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide 
• 1449278-70-9 8-amino-N-(azetidin-3-yl)-2-(3-fluorophenyl)-N-methyl-1,7-naphthyridine-5-carboxamide 
• 1449278-69-6 tert-butyl 3-[[8-amino-2-(3-fluorophenyl)-1,7-naphthyridine-5-carbonyl]amino]azetidine-1-carboxylate 

Relevant articles and documents

Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

Fascin is an actin binding and bundling protein that is not expressed in normal epithelial tissues but overexpressed in a variety of invasive epithelial tumors. It has a critical role in cancer cell metastasis by promoting cell migration and invasion. Here we report the crystal structures of fascin in complex with a series of novel and potent inhibitors. Structure-based elaboration of these compounds enabled the development of a series with nanomolar affinities for fascin, good physicochemical properties and the ability to inhibit fascin-mediated bundling of filamentous actin. These compounds provide promising starting points for fascin-targeted anti-metastatic therapies.