67970-91-6Relevant academic research and scientific papers
Highly c3-selective direct alkylation and arylation of 2-pyridones under visible-light-promoted photoredox catalysis
Najib, Atifah,Tabuchi, Sho,Hirano, Koji,Miura, Masahiro
, p. 1187 - 1203 (2016/07/26)
An Ir photoredox catalyst-mediated highly site-selective direct alkylation and arylation of 2-pyridones has been developed. Under visible-light-promoted conditions, ethyl 2-bromo-2,2-difluoroacetate couples with various 2-pyridones exclusively at the C3 position. A similar photoredox catalysis is also effective for the direct C3- Arylation with diaryliodonium triflates. Thus, these reactions occurs under very mild conditions (blue LEDs irradiation and ambient temperature) to form the corresponding C3- Alkylated and arylated 2-pyridones of potential interest in medicinal and pharmaceutical chemistry.
