67983-74-8 Usage
Chemical class
Synthetic steroid hormone
Subclass
Progestin
Derivative of
Norethisterone
Applications
Hormonal contraceptives, hormone replacement therapy
Structural similarity
Progesterone
Effects
Progestational and antiestrogenic
Mechanism of action in contraception
Inhibits ovulation, alters cervical mucus, and endometrial lining
Combination use
Often used with estrogen in oral contraceptive pills
Potential therapeutic effects
Treatment of endometriosis and menstrual disorders
Stereochemistry
(11b,17a)configuration
Molecular weight
Approximately 338.44 g/mol
Solubility
Generally lipophilic, soluble in organic solvents
Metabolism
Metabolized in the liver
Excretion
Primarily through the feces and, to a lesser extent, urine
Side effects
May include headaches, breast tenderness, changes in menstrual bleeding, and mood changes
Precautions
Not recommended for use in pregnancy, breastfeeding, or in individuals with certain medical conditions (e.g., liver disease, blood clotting disorders)
Drug interactions
May interact with other medications, including other hormonal contraceptives, anticonvulsants, and some antibiotics
Storage
Should be stored in a cool, dry place, protected from light and moisture
Regulatory status
Approved for use in various countries, subject to local regulations and guidelines
Check Digit Verification of cas no
The CAS Registry Mumber 67983-74-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,9,8 and 3 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 67983-74:
(7*6)+(6*7)+(5*9)+(4*8)+(3*3)+(2*7)+(1*4)=188
188 % 10 = 8
So 67983-74-8 is a valid CAS Registry Number.
67983-74-8Relevant academic research and scientific papers
REGIO AND STEREOSPECIFIC SYNTHESIS OF 11β-SUBSTITUTED 19-NORSTEROIDS. Influence of 11β-substitution on progesterone receptor affinity.
Belanger, A.,Philibert, D.,Teutsch, G.
, p. 361 - 382 (2007/10/02)
The convenient synthesis of a series of 11β-substituted 17-ethynyl-17β-hydroxy-4,9-estradien-3-ones and their corresponding estradiols is reported.Relative affinities for the progestin and estrogen receptors showed very specific interactions between the p
