6799-27-5 Usage
Uses
Used in Pharmaceutical Industry:
Tylophorinine is used as a pharmaceutical agent for its potential therapeutic effects. Its alkaloid nature suggests that it may have bioactive properties, which could be harnessed for the development of new drugs or treatments.
Used in Research and Development:
Tylophorinine serves as a subject of research for scientists studying the chemical properties and potential applications of alkaloids from natural sources. Its unique characteristics, such as optical rotation and UV absorption, make it an interesting compound for further investigation.
Used in Drug Delivery Systems:
Similar to gallotannin, Tylophorinine could potentially be incorporated into drug delivery systems to improve its bioavailability and therapeutic efficacy. The development of novel carriers and formulations could enhance the delivery of Tylophorinine to target tissues and cells, maximizing its potential benefits.
References
Hooper., Pharm. J., 21,6 (1891)
Chopra et al., Arch. Pharm., 275,236 (1937)
Govindachari, Pai, Nagarajan.,J. Chem. Soc., 2801 (1954)
Govindachari et al., Tetrahedron, 14,288 (1961)
Check Digit Verification of cas no
The CAS Registry Mumber 6799-27-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,7,9 and 9 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6799-27:
(6*6)+(5*7)+(4*9)+(3*9)+(2*2)+(1*7)=145
145 % 10 = 5
So 6799-27-5 is a valid CAS Registry Number.
InChI:InChI=1/C23H25NO4/c1-26-13-6-7-14-15(9-13)16-10-20(27-2)21(28-3)11-17(16)18-12-24-8-4-5-19(24)23(25)22(14)18/h6-7,9-11,19,23,25H,4-5,8,12H2,1-3H3
6799-27-5Relevant academic research and scientific papers
Asymmetric synthesis of phenanthroindolizidine alkaloids with hydroxyl group at the C14 position and evaluation of their antitumor activities
Ikeda, Takashi,Yaegashi, Takashi,Matsuzaki, Takeshi,Hashimoto, Syusuke,Sawada, Seigo
scheme or table, p. 342 - 345 (2011/02/27)
The asymmetric total synthesis of the strongly cytotoxic phenanthroindolizidine alkaloid 3 was achieved. Using the same route, various derivatives were also synthesized. Cytotoxicity of those synthetic compounds was evaluated and compounds 19, 23, and 27
Efficient and chirally specific synthesis of phenanthro-indolizidine alkaloids by parham-type cycloacylation
Wang, Ziwen,Li, Zheng,Wang, Kailiang,Wang, Qingmin
experimental part, p. 292 - 299 (2010/03/30)
A concise, efficient and modular route involving Parhamtype cycloacylation as the key step has been used to synthesize six enantiopure phenanthro- indolizidine alkaloids 1a-c. The preparation of enantiomerically pure tylophora alkaloids and their seco analogues on a large-scale is now feasible. The alcohol intermediates 8a-c, which are difficult to prepare by other synthetic methodologies, have been synthesized by a metallation-cyclization-reduction sequence in excellent yields.
