680-69-3Relevant academic research and scientific papers
Elemental fluorine. Part 9 : Catalysis of the direct fluorination of 2-substituted carbonyl compounds
Chambers, Richard D.,Hutchinson, John
, p. 45 - 52 (1998)
Catalysis of the reaction between fluorine and a range of 2-substituted carbonyl compounds has been investigated. Most notably, the preparation of diethyl-2-fluoromalonate has been achieved in high yield by fluorination of diethylmalonate in the presence of hydrated copper nitrate. Reactions between fluorine and carbanions derived from 2-substituted carbonyl compounds, including phosphonates, sulphones and nitriles, are also discussed.
