68007-03-4

Basic information

• Product Name: 2-HYDROXY-3-METHYL-5-NITRO-BENZALDEHYDE
• Synonyms: AKOS BB-6941;2-HYDROXY-3-METHYL-5-NITRO-BENZALDEHYDE;2-HYDROXY-5-NITRO-3-METHYLBENZALDEHYDE
• CAS NO: 68007-03-4
• Molecular Formula: C₈H₇NO₄
• Molecular Weight: 181.15
• Mol File: 68007-03-4.mol

Chemical Properties

• Boiling Point: 313.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.419±0.06 g/cm3(Predicted)
• PKA: 5.45±0.44(Predicted)
• CAS DataBase Reference: 2-HYDROXY-3-METHYL-5-NITRO-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-3-METHYL-5-NITRO-BENZALDEHYDE(68007-03-4)
• EPA Substance Registry System: 2-HYDROXY-3-METHYL-5-NITRO-BENZALDEHYDE(68007-03-4)

Safety Data

• Hazardous Substances Data: 68007-03-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-3-methyl-5-nitro-benzaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Dye and Pigment Production:
In the dye and pigment industry, 2-Hydroxy-3-methyl-5-nitro-benzaldehyde is utilized for the production of dyes and pigments, playing a crucial role in coloring textiles, plastics, and other materials.
Used in Photographic Chemicals Manufacturing:
2-Hydroxy-3-methyl-5-nitro-benzaldehyde is employed in the manufacturing of photographic chemicals, where it aids in the development of photographic films and papers.
Used in Antimicrobial Applications:
2-Hydroxy-3-methyl-5-nitro-benzaldehyde has been studied for its potential antimicrobial properties, making it a candidate for use in applications requiring the inhibition of microbial growth.
Used in Antioxidant Applications:
2-HYDROXY-3-METHYL-5-NITRO-BENZALDEHYDE has also been investigated for its antioxidant properties, suggesting its potential use in applications where protection against oxidative damage is necessary.

Upstream product

• 824-42-0 2-methoxy-3-methylbenzaldehyde 
• 383653-04-1 (3R,5S)-N-propanesulfonyl-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetamide 

Downstream Products

• 103027-94-7 8-methyl-6-nitro-coumarin 
• 103264-25-1 2-hydroxy-3-methyl-5-nitro-trans-cinnamic acid 

Relevant articles and documents

Chiral (1,2)-diphenylethylene-salen complexes of triel metals: Coordination patterns and mechanistic considerations in the isoselective ROP of lactide

The synthesis of enantiomerically pure aluminium, gallium and indium complexes supported by chiral (R,R)-(HHONNOHH) (1), (R,R)-(MeHONNOHMe) (2), (R,R)-(tButBuONNO tButBu) (3), (R,R)-(MeNO2ONNOMeNO2) (4), (R,R)-(HOMeONNOHOMe) (5) and (R,R)-( ClClONNOClCl) (6) (1,2)-diphenylethylene-salen ligands is described. Several of these complexes have been crystallographically authenticated, which highlights a diversity of coordination patterns. Whereas all Ga complexes form [Ga2(CH2SiMe3) 4(ONNO)] bimetallic species (ONNO=1-3), aluminium [AlR(ONNO)] (R=Me, CH2SiMe3) and indium [In(CH2SiMe 3)(ONNO)] derivatives are monometallic for ONNO=1, 2 and 4-6, and only form the bimetallic complexes [Al2R4(ONNO)] and [In2(CH2SiMe3)4(ONNO)] for the most sterically crowded ligand 3. The [AlMe(ONNO)] complexes react with iPrOH to give [AlOiPr(ONNO)] complexes that are robust towards further iPrOH. The [In(CH 2SiMe3)(ONNO)] congeners are inert towards excess alcohol, whereas the Ga compounds decompose easily. All these alkyl complexes, as well as the [AlOiPr(ONNO)] derivatives, catalyse the ring-opening polymerisation (ROP) of racemic lactide (rac-LA). The [AlMe(ONNO)] complexes require additional alcohol to afford controlled reactions, but [AlOiPr(ONNO)] complexes are single-component catalysts for the isoselective ROP of rac-LA, with values of Pm in the range 0.80-0.90. Experimental evidence unexpectedly shows that chain-end control leads to the isoselectivity of these aluminium catalysts; also, the more crowded the coordination sphere, the higher the isoselectivity. The bimetallic Ga complexes do not afford controlled reactions, but the binary [In(ONNO)(CH2SiMe3)/(PhCH2OH)] systems competently mediate non-stereoselective ROP; evidence is given that an activated monomer mechanism is at work. Kinetic studies show that catalytic activity decreases when electronic density and steric congestion at the metal atom increase. Class act: A new range of monometallic chiral salen-aluminium complexes based on a less-classical chiral backbone has been developed. These constitute efficient precatalysts for the isoselective ring-opening polymerisation of racemic lactide. According to chain-end control, they afford poly(lactide) (PLA) featuring high isotacticity (Pm≈0.80-0.90) in the upper range reported to date (see figure).

Benzoxazepinones and their use as squalene synthase inhibitors

There is disclosed a compound represented by the formula [I]: wherein R1 is optionally substituted 1-carboxyethyl group, optionally substituted alkyl-sulfonyl group, optionally substituted (carboxy-cycloalkyl)-alkyl group, -X1-X2-Ar-X3-X4-COOH (wherein X1 and X4 are a bond or alkylene group, X2 and X3 are a bond, -O-, -S-, Ar is divalent aromatic group etc.), R2 is alkyl group optionally substituted with alkanoyloxy group and/or hydroxy group, R3 is alkyl group, and W is halogen atom, etc., or a salt thereof. The compound has the cholesterol lowering activity and the triglyceride lowering activity and is useful for preventing and/or treating hyperlipidemia.