68009-14-3Relevant academic research and scientific papers
Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56Lck
Chen, Ping,Norris, Derek,Iwanowicz, Edwin J.,Spergel, Steven H.,Lin, James,Gu, Henry H.,Shen, Zhongqi,Wityak, John,Lin, Tai-An,Pang, Suhong,De Fex, Henry F.,Pitt, Sidney,Shen, Ding Ren,Doweyko, Arthur M.,Bassolino, Donna A.,Roberge, Jacques Y.,Poss, Michael A.,Chen, Bang-Chi,Schieven, Gary L.,Barrish, Joel C.
, p. 1361 - 1364 (2002)
We have identified a novel series of 1,5-imidazoquinoxalines as inhibitors of Lck with excellent potency (IC50s50s1 μM). Structure-activity studies demonstrate the requirement for the core heterocycle in addition to an optimal 2,6-disubstituted aniline group.
Method for treating fungal infection in mammals with imidazo [1,2-a]quinoxalines
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, (2008/06/13)
A method for treating a fungal infection in mammals which comprises administering to said mammals having a fungal infection a therapeutically effective amount of a 4-(substituted phenyl)imidazo[1,2-a]quinoxaline.
1-(2-Phenylureylene)imidazoles
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, (2008/06/13)
A 1-(2-acylaminophenyl)imidazole of formula: STR1 wherein R2 is hydrogen or a radical bonded to the nitrogen by a carbon to nitrogen linkage and selected from the group consisting of aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl, and monocyclic aryl substituted aliphatic groups.
1-(2-Acylaminophenyl)imidazoles
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, (2008/06/13)
A 1-(2-acylaminophenyl)imidazole of formula: STR1 wherein R5 is hydrogen or an aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl or monocyclic aryl substituted aliphatic group bonded to the carbonyl carbon through a carbon-to-carbon linkage. The compounds are useful as intermediates in the preparation of 4-substituted imidazo[1,2-a]quinoxalines.
