6801-59-8

Usage

Chemical Class

benzimidazoles

Derivative

1H-Benzimidazole with a (4-chlorophenoxy)methyl group and a 5-methyl group attached to the benzene ring

Potential Applications

pharmaceuticals, agrochemicals, and material science

Biological and Pharmacological Activities

antimicrobial, anti-inflammatory, and anticancer properties

Potential Use

pesticide or herbicide

Unique Feature

promising candidate for further research and development due to its molecular structure

Upstream product

• 122-88-3 4-Chlorophenoxyacetic acid 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 3598-13-8 (4-chlorophenoxy)acetonitrile 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of new antimicrobial active multisubstituted benzazole derivatives

A series of multisubstituted benzoxazoles, benzimidazoles, and benzothiazoles (5-7) as non-nucleoside fused isosteric heterocyclic compounds was synthesized and tested for their antibacterial activities against various Gram-positive and Gram-negative bacteria and antifungal activity against the fungus Candida albicans. Microbiological results indicated that the synthesized compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 100 and 3.12 μg/ml. Structure-activity relationships (SAR) studies revealed that benzothiazole ring system enhanced the antimicrobial activity against Staphylococcus aureus. In these sets of non-nucleoside fused heterocyclic compounds electron withdrawing groups at position 5 of the benzazoles increased the activity against C. albicans.

Synthesis and evaluation of a series of novel 2-[(4- chlorophenoxy)methyl]benzimidazoles as selective neuropeptide Y Y1 receptor antagonists

A series of novel benzimidazoles (BI) derived from the indole 2 was synthesized and evaluated as selective neuropeptide Y (NPY) Y1 receptor antagonists with the aim of developing antiobesity drugs. In our SAR approach, the (4-chlorophenoxy)methyl group at

Synthesis and microbiological activity of 5(or 6)-methyl-2-substituted benzoxazole and benzimidazole derivatives

The synthesis and microbiological activity of a new series of 5(or 6)- methyl-2-substituted benzoxazoles (IVa-n) and benzimidazoles (Va-h) were described. The in vitro microbiological activity of the compounds was determined against gram-positive, gram-ne