68018-54-2Relevant academic research and scientific papers
Synthesis, in silico and in vitro evaluation of antimicrobial and toxicity features of new 4‐[(4‐chlorophenyl)sulfonyl] benzoic acid derivatives
Apostol, Theodora-Venera,Barbuceanu, Stefania-Felicia,Chifiriuc, Mariana Carmen,Draghici, Constantin,Marutescu, Luminita Gabriela,Nitulescu, George Mihai,Olaru, Octavian Tudorel,Pahontu, Elena Mihaela,Saramet, Gabriel,Socea, Laura-Ileana
, (2021/08/30)
The multi‐step synthesis, physico‐chemical characterization, and biological activity of novel valine‐derived compounds, i.e., N‐acyl‐α‐amino acids, 1,3‐oxazol‐5(4H)‐ones, N‐acyl‐α-amino ketones, and 1,3‐oxazoles derivatives, bearing a 4‐[(4‐chlorophenyl)sulfonyl]phenyl moiety are reported here. The structures of the newly synthesized compounds were confirmed by spectral (UV‐Vis, FT‐IR, MS,1H‐ and13C‐NMR) data and elemental analysis results, and their purity was determined by RP‐HPLC. The new compounds were assessed for their antimicrobial activity and toxicity to aquatic crustacean Daphnia magna. Also, in silico studies regarding their potential mechanism of action and toxicity were performed. The antimicrobial evaluation revealed that the 2‐{4‐ [(4‐chlorophenyl)sulfonyl]benzamido}‐3‐methylbutanoic acid and the corresponding 1,3‐oxazol‐ 5(4H)‐one exhibited antimicrobial activity against Gram‐positive bacterial strains and the new 1,3‐ oxazole containing a phenyl group at 5‐position against the C. albicans strain.
Flow-vacuum pyrolysis of polycyclic compounds. 251. Pyrolysis of some 3-mercapto-5-substituted-1,2,4-triazoles
Istrati, Daniela,Popescu, Angela,Mihaiescu, Dan,Saramet, Ioana,Bala?u, Mihaela C.
scheme or table, p. 497 - 503 (2009/05/11)
The flow-vacuum pyrolysis (FVP) of the 3-mercapto-5-substituted-1,2,4- triazoles 5a-c, between 475°C - 750°C, at 2 mm Hg, in inert atmosphere (4mL/min argon flow rate) and quartz pyrolysis tube (60 cm length, 1 cm internal diameter, quartz chips filling 30 mm long) afforded a complex mixture with cyano-diphenyl-sulphones 12a-c and corresponding diphenylsulphones 13a-c as main products. The reaction products were identified by GC/MS. A radical mechanism is suggested in order to explain the formation of the main reaction products.
