680208-04-2

Upstream product

• 171178-50-0 2,6-difluoronicotinic acid 
• 680208-62-2 6-methoxy-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid 
• 92822-02-1 4-(4-fluorobenzyl)piperidine 
• 680208-00-8 N-{5-[4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-3-iodo-6-methoxy-pyridin-2-yl}-acetamide 
• 680207-98-1 (6-amino-5-iodo-2-methoxy-pyridin-3-yl)-[4-(4-fluoro-benzyl)-piperidin-1-yl]-methanone 
• 680207-96-9 (6-amino-2-methoxy-pyridin-3-yl)-[4-(4-fluoro-benzyl)-piperidin-1-yl]-methanone 
• 680207-92-5 (2,6-difluoro-pyridin-3-yl)-[4-(4-fluoro-benzyl)-piperidin-1-yl]-methanone 
• 680207-94-7 (6-Amino-2-fluoro-pyridin-3-yl)-[4-(4-fluoro-benzyl)-piperidin-1-yl]-methanone 
• 680208-02-0 N-{5-[4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-6-methoxy-3-trimethylsilanylethynyl-pyridin-2-yl}-acetamide 

Downstream Products

• 680207-91-4 1-{5-[4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl}-2-pyrrolidin-1-yl-ethane-1,2-dione 
• 680208-19-9 [4-(4-fluoro-benzyl)-piperidin-1-yl]-(6-methoxy-1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-methanone 

Relevant academic research and scientific papers

Piperidine-based heterocyclic oxalyl amides as potent p38α MAP kinase inhibitors

The design and synthesis of a new class of p38α MAP kinase inhibitors based on 4-fluorobenzylpiperidine heterocyclic oxalyl amides are described. Many of these compounds showed low-nanomolar activities in p38α enzymatic and cell-based cytokine TNFα produc

AZAINDOLE DERIVATIVES AS INHIBITORS OF P38 KINASE

The invention is directed to methods to inhibit p38 kinase, preferably p38-α using compounds which are azaindoles wherein the azaindoles are coupled through an azacyclic linker to another cyclic moiety.