680210-32-6Relevant articles and documents
A facile stereocontrolled approach to CF3-substituted triarylethenes: Synthesis of panomifene
Liu, Xinyu,Shimizu, Masaki,Hiyama, Tamejiro
, p. 879 - 882 (2007/10/03)
The stereoselective preparation and Pd-catalyzed cross-coupling reaction of boronates 2 provides a new general and convenient route to CF 3-substituted triaryl ethenes 3, in which the CF3 and Ar3 groups are cis to each other. The synthetic potential was demonstrated by the total synthesis of panomifene (Ar1 = Ar 3 = Ph, Ar2 = 4-(OHCH2CH2NHCH 2CH2O)-C6H4). Bpin = (pinacolato)boryl.