680230-04-0

Upstream product

• 2491-20-5 L-alanine methyl ester hydrochloride 
• 105184-38-1 3,5-difluorophenyl acetic acid 

Downstream Products

• 680228-35-7 N₁-[(2R,3R)-7-chloro-2-(2,5-difluorophenyl)-4-oxo-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-N₂-[(3,5-difluorophenyl)acetyl]-L-alaninamide 
• 680227-90-1 N₂-[(3,5-difluoro-phenyl)acetyl]-N₁-[(2R,3R)-2-(2,5-difluoro-phenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-L-alaninamide 
• 680228-55-1 N₂-[(3,5-difluorophenyl)acetyl]-N₁-[(2R,3S)-4-oxo-2-phenyl-5-prop-2-yn-1-yl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-L-alaninamide 
• 680228-60-8 N₁-[(2R,3S)-5-(cyclopropylmethyl)-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-N₂-[(3,5-difluorophenyl)acetyl]-L-alaninamide 
• 680229-09-8 N₂-[(3,5-difluoro-phenyl)acetyl]-N₁-[(3S,4R)-8-fluoro-2-oxo-4-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]-L-alaninamide 
• 680229-48-5 N₁-[(2R,3S)-7-chloro-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-N₂-[(3,5-difluorophenyl)acetyl]-L-alaninamide 
• 680229-59-8 N₂-[(3,5-difluorophenyl)acetyl]-N₁-[(2R,3S)-7-fluoro-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-L-alaninamide 
• 680228-57-3 N₂-[(3,5-difluorophenyl)acetyl]-N₁-[(2R,3S)-5-isopropyl-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-L-alaninamide 
• 1356955-76-4 (S)-N-[4-(6-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[4,5-c]pyridin-2-yl)phenyl]-2-[2-(3,5-difluorophenyl)acetamido]propanamide 
• 208124-34-9 N-(3,5-Difluorophenylacetyl)-L-alanine 

Relevant academic research and scientific papers

Identification of new aminoacid amides containing the imidazo[2,1-b] benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling

The Met receptor tyrosine kinase is a promising target in anticancer therapies for its role during tumor evolution and resistance to treatment. It is characterized by an unusual structural plasticity as its active site accepts different inhibitor binding

Synthesis of a tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity

A straightforward synthesis of the Met antagonist JLK1360 involving an alkylationcyclocondensation process using aminothiazole 1 and nitrophenacyl bromide 2, reduction of the nitro group, and coupling of the resulting tetracyclic aniline 5 with an appropr

CHEMICAL COMPOUNDS

The invention provides a new method for treating disorders associated with activation of the Notch signal transduction pathway comprising administering an effective amount of a compound of Formula (I), in free form or in a pharmaceutically acceptable salt

NOVEL LACTAMS AND USES THEREOF

Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid ? protein production and neurological disorders such as Alzheimer's disease.. These compounds inhibit γ secretase and thereby inhibit the production of amyloid ? protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.