680230-04-0

Basic information

• Product Name: L-Alanine, N-[(3,5-difluorophenyl)acetyl]-, methyl ester
• CAS NO: 680230-04-0
• Molecular Formula: C12H13F2NO3
• Molecular Weight: 257.237
• Mol File: 680230-04-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: L-Alanine, N-[(3,5-difluorophenyl)acetyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-[(3,5-difluorophenyl)acetyl]-, methyl ester(680230-04-0)
• EPA Substance Registry System: L-Alanine, N-[(3,5-difluorophenyl)acetyl]-, methyl ester(680230-04-0)

Safety Data

• Hazardous Substances Data: 680230-04-0(Hazardous Substances Data)

Upstream product

• 2491-20-5 L-alanine methyl ester hydrochloride 
• 105184-38-1 3,5-difluorophenyl acetic acid 

Downstream Products

• 680228-35-7 N₁-[(2R,3R)-7-chloro-2-(2,5-difluorophenyl)-4-oxo-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-N₂-[(3,5-difluorophenyl)acetyl]-L-alaninamide 
• 680227-90-1 N₂-[(3,5-difluoro-phenyl)acetyl]-N₁-[(2R,3R)-2-(2,5-difluoro-phenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-L-alaninamide 
• 680228-55-1 N₂-[(3,5-difluorophenyl)acetyl]-N₁-[(2R,3S)-4-oxo-2-phenyl-5-prop-2-yn-1-yl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-L-alaninamide 
• 680228-60-8 N₁-[(2R,3S)-5-(cyclopropylmethyl)-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-N₂-[(3,5-difluorophenyl)acetyl]-L-alaninamide 
• 680229-09-8 N₂-[(3,5-difluoro-phenyl)acetyl]-N₁-[(3S,4R)-8-fluoro-2-oxo-4-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]-L-alaninamide 
• 680229-48-5 N₁-[(2R,3S)-7-chloro-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-N₂-[(3,5-difluorophenyl)acetyl]-L-alaninamide 
• 680229-59-8 N₂-[(3,5-difluorophenyl)acetyl]-N₁-[(2R,3S)-7-fluoro-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-L-alaninamide 
• 680228-57-3 N₂-[(3,5-difluorophenyl)acetyl]-N₁-[(2R,3S)-5-isopropyl-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-L-alaninamide 
• 1356955-76-4 (S)-N-[4-(6-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[4,5-c]pyridin-2-yl)phenyl]-2-[2-(3,5-difluorophenyl)acetamido]propanamide 
• 208124-34-9 N-(3,5-Difluorophenylacetyl)-L-alanine 

Relevant articles and documents

Identification of new aminoacid amides containing the imidazo[2,1-b] benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling

The Met receptor tyrosine kinase is a promising target in anticancer therapies for its role during tumor evolution and resistance to treatment. It is characterized by an unusual structural plasticity as its active site accepts different inhibitor binding

CHEMICAL COMPOUNDS

The invention provides a new method for treating disorders associated with activation of the Notch signal transduction pathway comprising administering an effective amount of a compound of Formula (I), in free form or in a pharmaceutically acceptable salt