68044-72-4Relevant academic research and scientific papers
IMIDAZO[4,5-B]PYRIDINE DERIVATIVES AS CARDIOVASCULAR AGENTS
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, (2008/06/13)
Disclosed are the compounds of the formula STR1 wherein R represents hydrogen, lower alkyl, aryl or aryl-lower alkyl; R 1 represents hydrogen, lower alkyl, C 3-C 7-alkenyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, C 3-C 7-cycloalkyl, or optionally lower alkyl substituted (C 3-C. sub.7-cycloalkyl, bicycloheptyl, bicycloheptenyl, adamantyl, tetrahydropyranyl or tetrahydrothiopyranyl)-lower alkyl, or diaryl-lower alkyl; R 2 represents hydrogen or lower alkyl; R 3 represents hydroxymethyl or--CONHR 4 in which R 4 represents hydrogen, lower alkyl, aryl-lower alkyl, C 3-C 7-cycloalkyl, C 3-C. sub.7-cycloalkyl-lower alkyl or hydroxy-lower alkyl; pharmaceutically acceptable ester derivatives thereof in which one or more of the hydroxy groups are esterified in form of a pharmaceutically acceptable ester; and pharmaceutically acceptable salts thereof; methods of preparation; pharmaceutical compositions; and their use as adenosine-2 agonists in mammals.
