68057-10-3

Basic information

• Product Name: N-benzyl-2,2-diethoxyacetamide
• Synonyms: N-benzyl-2,2-diethoxyacetamide
• CAS NO: 68057-10-3
• Molecular Weight: 237.299
• Mol File: 68057-10-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-benzyl-2,2-diethoxyacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2,2-diethoxyacetamide(68057-10-3)
• EPA Substance Registry System: N-benzyl-2,2-diethoxyacetamide(68057-10-3)

Safety Data

• Hazardous Substances Data: 68057-10-3(Hazardous Substances Data)

Upstream product

• 16326-34-4 diethoxymethyl acetate 
• 100-46-9 benzylamine 
• 61189-99-9 diethoxyacetamide 

Relevant articles and documents

Ammonium nitrate: A biodegradable and efficient catalyst for the direct amidation of esters under solvent-free conditions

A simple, metal-free, and environment-friendly procedure is developed for the direct conversion of esters to amides using ammonium nitrate as a catalyst under solvent-free conditions. Aryls, heteroaryls, and aliphatic esters are easily converted to the corresponding amides in excellent isolated yields (85-99%). An enantiopure ester and amine were both shown to react without racemization. The methodology has been successfully applied to preparation of procainamide.

Transamidation of primary amides with amines catalyzed by zirconocene dichloride

Zirconocene dichloride (Cp2ZrCl2) has been shown to be an effective catalyst for the transamidation of primary amides with amines in cyclohexane at 80°C in 5-24 hours. For favourable substrates, the reaction can be performed at temperatures as low as 30°C.